Solid-SMEDDS: Techniques of Solidification and Recent Advancements

From the point of view of dosage forms, S-SEDDS represents the solid dose formulation with self-emulsification features. The S-SEDDS becomes the focal point when adding liquid or semisolid SE components into powders or nanoparticles through various solidification strategies, such as adsorption to solid carriers, spray drying, spray cooling, supercritical liquid-based technique, melt extrusion, nanoparticle technology, etc. S-SMEDDS offers various benefits, such as diminishing the threat of interaction of the SMEDDS ingredients with the shell of the capsule. Immediate or controlled-release formulations can be formulated, relying upon the decision of the powder ingredient to be incorporated in the formulation; SE granules or pellets diminish the rate of the gastric emptying time and smooth entry in the gut, which generally leads to less threat of dosage fluctuations. Various types of S-SMEDDS include SE solid dispersions, SE tablets, SE enteric-coated dry emulsion, SE beads, SE sustained-release microspheres, SE nanoparticles, SE mouth dissolving film, SE floating dosage form, positively charged SMEDDS, self-double-emulsifying drug delivery system, supersaturatable SMEDDS, and so on. While lecithin-linker SEFs, sponges carrying SMEDDS, herbal SMEDDS and SE phospholipid suspension are novel S-SMEDDS. Different issues are related to the solidification strategies, such as the quantity of solidifying ingredients, the release rate of the drug, degradation of drug amid solidifying procedure, difficulty in content uniformity, decrease in drug loading limit and the probability of remaining solvents amid granulation and so on. In this chapter, an attempt has been made to highlight the various methods for solidifying SMEDDS, their issues and types of Solid- SMEDDS.

Keywords: Nanoparticles, Self-double-emulsifying drug delivery system techniques, SE pellets, SE mouth dissolving films, SE phospholipid suspension, Solid self-microemulsifying drug delivery system.