miRNA and Nanoparticle Conjugate as a Future Therapeutic Approach

Abstract

Micro RNAs are naturally occurring RNA molecules that help in the degradation of mRNA molecules sequence specifically. They degrade the mRNA molecules and thus inhibit the formation of protein after translation. miRNA expression varies from tissue to tissue and from one disease condition to other. Thus this molecule becomes a target of therapy in various types of disease conditions. But, the use of bare miRNAs has several drawbacks as they may degrade in the body fluid due to their fragile nature. So, in this regard nanoparticles have a very vital role to overcome these disadvantages. In this study, we intended to discuss the various forms of miRNA therapeutic approaches, along with various types of nanoparticles that may carry the miRNA and its antagomirs to the target site.

Keywords: Aptamer nanoparticle, Chitosan nanoparticle, Circulating miRNA, Cyclodextrin nanoparticle, Dendrimer nanoparticle, Gold nanoparticle, Graphine nanoparticle, Inorganic nanoparticle, Lipid nanoparticle, miRNA, miRNA replacement therapy, miRNA suppression therapy, Magnetic nanoparticle, Mesoporous silica nanoparticle, Off target effect, Organic nanoparticle, PLGA nanoparticle, Polyethyleneimine nanoparticle, Polymeric nanoparticle, Protein nanoparticle, Quantum dote nanoparticle, Stability.