Abstract
Although others and we have earlier reported that the amelogenins play critical roles in proper enamel formation, the in vivo functions of each of the amelogenin isoforms have not been clearly defined because of their heterogeneity and complexity. This chapter will review the current information on the functions of amelogenin splice isoforms, full length amelogenin and leucine rich amelogenin peptide (LRAP), in enamel formation. We will also discuss the emerging evidence for the additional role of LRAP as a signaling molecule in mesenchymal cells of the periodontal tissues. We believe that further insights into the signaling pathway modulated by the multifunctional amelogenin proteins will lead to development of new therapeutic approaches to treat dental diseases and disorders.
Keywords: Amelogenin, Mouse Model, M180, Leucine rich Amelogenin Peptide (LRAP), Signaling Molecules
About this chapter
Cite this chapter as:
Naoto Haruyama, Junko Hatakeyama, Yuji Hatakeyama, Carolyn W. Gibson, Ashok B. Kulkarni ;Lessons from the Amelogenin Knockout Mice, Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair (2010) 1: 25. https://doi.org/10.2174/978160805171711001010025
DOI https://doi.org/10.2174/978160805171711001010025 |
Print ISSN 2589-3076 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-2841 |