In-Silico and In-Vitro Approaches to Screen the Antituberculosis Activity of Benzothiazole Analogs

Synthesis and Anti-TB Activity Screening of Benzothiazole Amide Derivatives

Author(s): Mahesh Bhat and S.L. Belagali

Pp: 66-76 (11)

DOI: 10.2174/9789811494635121010007

* (Excluding Mailing and Handling)

Abstract

Synthesis of diamide derivatives are carried out by the phenylalanine initially phenylalanine reacts with the aromatic amine by the acid amine coupling followed by de-protection of the boc and further reacts with the benzothiazole carboxylic acid by the formation of the amide coupling in the presence HATU as coupling reagent. Further series of the diamide benzothiazole derivative compounds were screened for the in-silico and in-vitro anti TB activity. In in-silico method compounds show a good docking score with respect to the standard drug. In-vitro Alamar blue assay demonstrate some of the compounds marked for the superior activity with minimum inhibitory concentration 1.6 μg/mL.


Keywords: Alamar Blue Assay, Amide, Anti-TB, Benzothiazole, Boc, Diethyl oxalate, DIPEA, Docking, DprE1, HATU, InhA, Isoniazid, MIC, Phenyl alanine, Pyrazinamide, T3P, Trifluoro acetic acid, Triethylamine, Tuberculosis.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version190msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[23:31:44] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (103ms)time
  • Application (86.31ms)time
  • 1 x Booting (54.49%)
    103ms
    1 x Application (45.51%)
    86.31ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed24.31ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('59694094','',1,1739835104,1739835104) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739835104
      1.19msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('59694094','/chapter/14602',1,1739835104,1739835104)
      160μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59694094 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59694094) limit 1
      13msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59694094
      • 1: 59694094
      • 2: 59694094
      • 3: 59694094
      • 4: 59694094
      • 5: 59694094
      • 6: 59694094
      • 7: 59694094
      • 8: 59694094
      • 9: 59694094
      • 10: 59694094
      • 11: 59694094
      • 12: 59694094
      • 13: 59694094
      • 14: 59694094
      • 15: 59694094
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '14602' limit 1
      260μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 14602
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '14602' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      640μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 14602
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '14602'
      320μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 14602
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 852 limit 1
      270μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 852
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=852) and se.ebook_id!=852 and v.ebook_status='1'
      2.78msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=852) and se.ebook_id!=852 and v.ebook_status='1' limit 10 offset 0
      810μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=852)
      490μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=852) limit 10 offset 0
      490μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 3047 and `e`.`is_uploaded` = 1
      520μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 3047
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 852 and ebook_volume_id <> 3047 limit 1
      290μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 852
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '14602' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      280μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '3047' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      250μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59694094 and j.to_ip >=59694094 )) and ((j.from_date <= 1739835104 and j.to_date >= 1739835104 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3047) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59694094 and j.to_ip >=59694094 )) and ((j.from_date <= 1739835104 and j.to_date >= 1739835104 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3047) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59694094 and j.to_ip >=59694094 )) and ((j.from_date <= 1739835104 and j.to_date >= 1739835104 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3047)
      590μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59694094 and j.to_ip >=59694094 )) and ((j.from_date <= 1739835104 and j.to_date >= 1739835104 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14602) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59694094 and j.to_ip >=59694094 )) and ((j.from_date <= 1739835104 and j.to_date >= 1739835104 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14602) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59694094 and j.to_ip >=59694094 )) and ((j.from_date <= 1739835104 and j.to_date >= 1739835104 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14602)
      540μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3047 and `b`.`banner_from_date` <= 1739835104 and `b`.`banner_to_date` >= 1739835104 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.16msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3047
      • 3: 1739835104
      • 4: 1739835104
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='e0c13310c52ac613ff0af4d093571d4b'
      270μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    19Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        a3B4D7n1xm1Z2vHHd7CoQBtDnJ33xlzHrThKOpjh
        uc_cart_id
        e0c13310c52ac613ff0af4d093571d4b
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14602" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/14602
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "_ga=GA1.1.702132085.1739835103; wayfindertarget=eyJpdiI6ImJVWlhvbVhsc3dWdHVaVmwvUWJqbEE9PSIsInZhbHVlIjoib2I4Rm0xTzVrTEVKdDBjWkJYaEZzZHFmdzVMY3ZFakNEUmRZSU9lR2JzND0iLCJtYWMiOiJlZDFlNWVmZWQyNGUwOTdhYzMwYmNiMTQxNzg2M2Q0NjVhZWIwOWVjZjdjMjEwNzQ5ZGI4ZmRhODVkYmVhMmE3IiwidGFnIjoiIn0%3D; _ga_9F3B5VV3T3=GS1.1.1739835102.1.1.1739835102.60.0.0; fpestid=zAjT8NsV8NqaNsoc-7RZ97HJ_4S8bzj32bwbUFNNvuEHawb1AIjbwrstM2ggetYMovKd3g_ga=GA1.1.702132085.1739835103; wayfindertarget=eyJpdiI6ImJVWlhvbVhsc3dWdHVaVmwvUWJqbEE9PSIsInZhbHVlIjoib2I4Rm0xTzVrTEVKdDBjWkJYaEZzZHFmdzVMY3ZFakNEUmRZSU9lR2Jz" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:4 [ "_ga" => null "wayfindertarget" => null "_ga_9F3B5VV3T3" => null "fpestid" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 17 Feb 2025 23:31:44 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjhtWmxDZUFIcGwxOEZZc1A5OXlCNmc9PSIsInZhbHVlIjoiaktHS3krNzNKdUN2RjZ1MzhIcHVuTVNxb1NXTkxxVGoxTTFyVGhDN3h4b3VsaDFleFVPMFNQQ1F6eFI1LzdtelFnTGFGdW1zUVl5N3FnK3hEZ1hKM2ZlTEczVjZCQ3duUmhZSkhjK0Y5YytQd2RkRXJmZUJ6WktITFlZM1EwdzYiLCJtYWMiOiI0MTU5YjM5MjI5YWEwNDRmNTBlNGIwOGE1NWZjM2FhYWFkMDFjYWZkNWY3OTVmZTgzYzNlMjliMjcwZmY5Zjg3IiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 11:31:44 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IjhtWmxDZUFIcGwxOEZZc1A5OXlCNmc9PSIsInZhbHVlIjoiaktHS3krNzNKdUN2RjZ1MzhIcHVuTVNxb1NXTkxxVGoxTTFyVGhDN3h4b3VsaDFleFVPMFNQQ1F6eFI1LzdtelFnTGFGd" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ii9vcWk4ZmRnbkRDZWpYRkdnQlBRdVE9PSIsInZhbHVlIjoibUpoWk5ORFkrLzZHQVNJMU5PZ3N1b0praGxSNU5JUlU4aU1oV3FNRytBMSs3VTViMk9LQk5jZk1neENuR1lqZFZpdkNUMkZkeVlTRnhodmNTYUczamJvUkdCZTk5MTdiSWgvTlFlTTFGYjNhU2h3L2l2bkM1Z1FjZHlKTFNoVTUiLCJtYWMiOiI1OTFmZDE1Y2IwNzEzMGFjOTdhNTBmNWU0YjJiZWY1NGQ4MDU5MDk4M2Q4N2I1NzkwOTY1MDk4YTcyODRlMzA5IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ii9vcWk4ZmRnbkRDZWpYRkdnQlBRdVE9PSIsInZhbHVlIjoibUpoWk5ORFkrLzZHQVNJMU5PZ3N1b0praGxSNU5JUlU4aU1oV3FNRytBMSs3VTViMk9LQk5jZk1" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjhtWmxDZUFIcGwxOEZZc1A5OXlCNmc9PSIsInZhbHVlIjoiaktHS3krNzNKdUN2RjZ1MzhIcHVuTVNxb1NXTkxxVGoxTTFyVGhDN3h4b3VsaDFleFVPMFNQQ1F6eFI1LzdtelFnTGFGdW1zUVl5N3FnK3hEZ1hKM2ZlTEczVjZCQ3duUmhZSkhjK0Y5YytQd2RkRXJmZUJ6WktITFlZM1EwdzYiLCJtYWMiOiI0MTU5YjM5MjI5YWEwNDRmNTBlNGIwOGE1NWZjM2FhYWFkMDFjYWZkNWY3OTVmZTgzYzNlMjliMjcwZmY5Zjg3IiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 11:31:44 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IjhtWmxDZUFIcGwxOEZZc1A5OXlCNmc9PSIsInZhbHVlIjoiaktHS3krNzNKdUN2RjZ1MzhIcHVuTVNxb1NXTkxxVGoxTTFyVGhDN3h4b3VsaDFleFVPMFNQQ1F6eFI1LzdtelFnTGFGd" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ii9vcWk4ZmRnbkRDZWpYRkdnQlBRdVE9PSIsInZhbHVlIjoibUpoWk5ORFkrLzZHQVNJMU5PZ3N1b0praGxSNU5JUlU4aU1oV3FNRytBMSs3VTViMk9LQk5jZk1neENuR1lqZFZpdkNUMkZkeVlTRnhodmNTYUczamJvUkdCZTk5MTdiSWgvTlFlTTFGYjNhU2h3L2l2bkM1Z1FjZHlKTFNoVTUiLCJtYWMiOiI1OTFmZDE1Y2IwNzEzMGFjOTdhNTBmNWU0YjJiZWY1NGQ4MDU5MDk4M2Q4N2I1NzkwOTY1MDk4YTcyODRlMzA5IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ii9vcWk4ZmRnbkRDZWpYRkdnQlBRdVE9PSIsInZhbHVlIjoibUpoWk5ORFkrLzZHQVNJMU5PZ3N1b0praGxSNU5JUlU4aU1oV3FNRytBMSs3VTViMk9LQk5jZk1" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "a3B4D7n1xm1Z2vHHd7CoQBtDnJ33xlzHrThKOpjh" "uc_cart_id" => "e0c13310c52ac613ff0af4d093571d4b" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14602" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:31:44GET/chapter/146021121921