Topics in Anti-Cancer Research

Volume: 9

ShcA Family of Adaptor Proteins: Dual Role in Cell Growth

Author(s): Hilal Ahmad Mir, Roshia Ali and Firdous A. Khanday

Pp: 74-96 (23)

DOI: 10.2174/9789811476600120090006

* (Excluding Mailing and Handling)

Abstract

ShcA proteins are the family of adaptor proteins that mediate biological responses by transducing extracellular signals into intracellular signals. ShcA family consists of three different alternatively spliced or alternative translational initiated isoforms known as p66Shc, p52Shc and p46Shc. The p52and p46Shc isoforms are usually involved in promoting cell growth, mediating their action by activating mitogen-activated protein kinases (MAPK) and phosphoinositide-3-kinase/Akt signalling pathways. However, the p66Shc isoform acts as a dual player in cell development and is involved in stimulating both cell proliferative and apoptotic pathways. Any deregulation in the expression of ShcA proteins and pathways regulated by ShcA proteins results in the occurrence of different types of cancerous diseases, including breast cancer, thyroid cancer, prostate cancer and lung cancer. Aberrations in the expression of ShcA proteins have been demonstrated to promote key elements of cancer progression, including cell migration, cell proliferation, metabolic reprogramming, angiogenesis and tumorigenesis. Based on all these studies, the present chapter focuses on the structure of ShcA proteins and their role in promoting metastasis and progression of various cancers. Understanding the role of ShcA proteins may provide new tools for therapeutic interventions in dreadful cancer disease.


Keywords: Adaptor proteins, Apoptosis, Aging, Cell proliferation, Cell differentiation, Cell signalling, Cell survival, Metabolism, Modular domains, Neoplasms, Oxidative stress, Reactive oxygen species, Vascularization.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51322660 and j.to_ip >=51322660 )) and ((j.from_date <= 1740774647 and j.to_date >= 1740774647 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14424) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51322660 and j.to_ip >=51322660 )) and ((j.from_date <= 1740774647 and j.to_date >= 1740774647 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14424) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51322660 and j.to_ip >=51322660 )) and ((j.from_date <= 1740774647 and j.to_date >= 1740774647 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14424)
      910μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2920 and `b`.`banner_from_date` <= 1740774647 and `b`.`banner_to_date` >= 1740774647 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.18msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2920
      • 3: 1740774647
      • 4: 1740774647
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='c2453beaac95223e2d3f0c283ef7b42c'
      780μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:291
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    13Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        0s6WgZWnXPxxMRF26poYVyadxvtuMaveMYQjMatw
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14424" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        uc_cart_id
        c2453beaac95223e2d3f0c283ef7b42c
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/14424
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IlIvS0g5OGcwWHhSM2ZPLzFTdi9KUUE9PSIsInZhbHVlIjoiNHFYNDVaM2NoZGJrVUlFNlBqN1hKbGhSRWp5dTlMWVd6ZW42RGIyaGlIZz0iLCJtYWMiOiI3YmZlMzk2Nzc1OGZhZGIzZGEwMjg3YjYxZDMxZjI4ZmI5NGRiNzRiYjM2NmFlNWVkZWJkOTA2M2ViMWFkNjkzIiwidGFnIjoiIn0%3D; XSRF-TOKEN=eyJpdiI6IkowaXNldUxtSktnSzI5eEN5QXozOEE9PSIsInZhbHVlIjoibG9oKzU1Ry9aclBFV0pWSDRKbXZVOFkxWFZKd21QamI1WFFZK2VRRmlEZjl0TnJORG1xQmVOSEk5V2NjbVkydTBFT1dIRERET0xhSGI4NEtRbzRxaWdla1pLc0VBb0hkY2RCMnBzVEVkaXp5YlFKSWVhS0x5WHpFYTdubFlyZ3YiLCJtYWMiOiI5MTI4MzI4N2I4M2UyZGM4MmVjZDcyZmZmOTdjOWMzMDg5YmEzZGFmYjQ3YjdkZmU4ZGM1MzVmOTU5NDljZWRkIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6ImdQWklweExvY0dJRzJ6c1JVbVYvaUE9PSIsInZhbHVlIjoiZUw3RUorcS9CRXVORUY3eVY5ZmNiandmSlNJUnowRWhmdTlqTlpFQUNFdnIrSDNNN3pOUG15SWY4OE1YNWtjQm1RaW1sY1hUbDJMR0d3RFhtUnlVUCtOQk5pSlo0YXVNTGFIeEZ3eWdQUUVTbGJ1YVNwcUI0MVRiMTh5QnM4TysiLCJtYWMiOiIzYmI1ZDJjYTMwNTgwNmRlYzMwZWQ4MWI4N2QxYTMyNmU5MmVmNTdkZmQxNTFlNzA0MTJjNzUzZTdjYzExMDA2IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IlIvS0g5OGcwWHhSM2ZPLzFTdi9KUUE9PSIsInZhbHVlIjoiNHFYNDVaM2NoZGJrVUlFNlBqN1hKbGhSRWp5dTlMWVd6ZW42RGIyaGlIZz0iLCJtYWMiOiI3YmZlMzk2Nzc1OGZh" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-28 20:30:47GET/chapter/144241121915