Advances in Cancer Signal Transduction and Therapy

The Tumor Microenvironment Mediated Signaling Pathways in the Progression of Acute Myeloid Leukemia

Author(s): Anup S. Pathania, Rachel Weber and Kishore B. Challagundla

Pp: 159-183 (25)

DOI: 10.2174/9789811458118120010010

* (Excluding Mailing and Handling)

Abstract

Acute myeloid leukemia (AML) is a cancer of blood and bone marrow, caused by abnormal production of white blood cells. According to the recent 2020 statistics, an estimated number of 19,940 people in the United States will be diagnosed with AML. The hematologic tumor microenvironment plays a critical role in the progression of AML. Emerging evidence indicates that chemotherapy resistance and disease relapse are linked through the signaling pathways associated with the tumor microenvironment in AML. The leukemia cells communicate with the other noncancerous cells of the tumor microenvironment through small vesicles that are within the size of 30-120nm called exosomes, a type of extracellular vesicles. Exosomes contain genetic information in their cargo, in the form of either protein, DNA, or noncoding RNAs and communicate to the distinct cells through various signaling pathways. The c-Myc oncogenic transcription factor protein is a master regulator of oncogenic signaling pathways in various cancers, including AML. C-Myc has been associated with the development of therapy resistance in AML, representing a key target. The interconnection between exosomes, tumor microenvironment, c-Myc and the development of progression, therapy resistance are discussed in this chapter and thus, represents a fundamental knowledge of the recent advances in cancer signal transduction and therapy.


Keywords: Acute myeloid leukemia, C-Myc, Drug resistance, Exosomes, Oncogene, Tumor microenvironment, Tumor suppressor gene.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version195msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[03:10:37] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (106ms)time
  • Application (88.74ms)time
  • 1 x Booting (54.44%)
    106ms
    1 x Application (45.55%)
    88.74ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed26.32ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316452332','',1,1739848237,1739848237) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739848237
      1.01msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316452332','/chapter/14059',1,1739848237,1739848237)
      210μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316452332 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316452332) limit 1
      13.69msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316452332
      • 1: 316452332
      • 2: 316452332
      • 3: 316452332
      • 4: 316452332
      • 5: 316452332
      • 6: 316452332
      • 7: 316452332
      • 8: 316452332
      • 9: 316452332
      • 10: 316452332
      • 11: 316452332
      • 12: 316452332
      • 13: 316452332
      • 14: 316452332
      • 15: 316452332
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '14059' limit 1
      380μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 14059
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '14059' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.83msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 14059
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '14059'
      1.35msalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 14059
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 824 limit 1
      280μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 824
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=824) and se.ebook_id!=824 and v.ebook_status='1'
      1.67msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=824) and se.ebook_id!=824 and v.ebook_status='1' limit 10 offset 0
      830μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=824)
      440μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=824) limit 10 offset 0
      490μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 2889 and `e`.`is_uploaded` = 1
      530μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 2889
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 824 and ebook_volume_id <> 2889 limit 1
      290μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 824
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '14059' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      330μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '2889' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      370μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316452332 and j.to_ip >=316452332 )) and ((j.from_date <= 1739848237 and j.to_date >= 1739848237 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2889) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316452332 and j.to_ip >=316452332 )) and ((j.from_date <= 1739848237 and j.to_date >= 1739848237 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2889) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316452332 and j.to_ip >=316452332 )) and ((j.from_date <= 1739848237 and j.to_date >= 1739848237 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2889)
      650μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316452332 and j.to_ip >=316452332 )) and ((j.from_date <= 1739848237 and j.to_date >= 1739848237 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14059) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316452332 and j.to_ip >=316452332 )) and ((j.from_date <= 1739848237 and j.to_date >= 1739848237 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14059) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316452332 and j.to_ip >=316452332 )) and ((j.from_date <= 1739848237 and j.to_date >= 1739848237 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14059)
      670μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2889 and `b`.`banner_from_date` <= 1739848237 and `b`.`banner_to_date` >= 1739848237 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.08msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2889
      • 3: 1739848237
      • 4: 1739848237
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='6162c8ddadc102cc8e7e93233fe795ec'
      220μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    7Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        pRW4rBEoH99KiqQ628AJpVMj1Zgy78qCmej6CugK
        uc_cart_id
        6162c8ddadc102cc8e7e93233fe795ec
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14059" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/14059
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "fpestid=7KlDgsQ1KXmHG80Z4LVZcgEjUcAgREiCur_p3PnaVypzdvlYZJRc_wnkuGjuDfDjYiklQQ; _ga_9F3B5VV3T3=GS1.1.1739848225.1.0.1739848225.60.0.0; _ga=GA1.1.1838635158.1739848226; wayfindertarget=eyJpdiI6Inl5QlBHSmppeWZEQlh1RFQyMkRwYUE9PSIsInZhbHVlIjoid0djOUJGZ1RUcmFhQzV5elc1WjlkYlM5ZHdoNy9GcHI0SGl6S3FCLzBycjlpWHM4UDdQUVFRTU5TaFBZY3hxUiIsIm1hYyI6IjU4Y2U2NmRjMmFmNDZiMWI5MjUxMDBiODA0NDJmOGU1ZjU5MGVhM2E5NjIzMjc4MTk1ZjE0NTk2OGU0NzQyZDkiLCJ0YWciOiIifQ%3D%3D; XSRF-TOKEN=eyJpdiI6ImttMlpQeGhyZUxEeDFHcWdWRVFNckE9PSIsInZhbHVlIjoicDk2TUVQNmt6SDdBSU9wQ3JadmpvcklYYmY4Rzd1SGJDVUYxVnY2OVJoQjUwams2N2JQOHJqYVUwQzRFY0h0RTVWT2ZYeTNRNk5EL3J3dWE4MjdiaUEwMDF1V0NvOXlPdmgralNxRWdML0RHcEtaV252WUpRYUhjTnY1VURCYkgiLCJtYWMiOiIxODllODhhZjhlNjFlNWI3M2I3NTZmM2YwYmNmNzZlZmY0NzJmMWM5NmIxYzc0YTc3YmFiNWY3OGM3MjA3ZWM3IiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6ImhsUGEwM0JhWEdFWU00WUthdXhrekE9PSIsInZhbHVlIjoiVFAwNitDL2pqNGpiTm0zZitWQmVnZnZKYmhjYWxFb3d0NFludTczS2JyRHJqNmxlV2JQUC9vRFVnMTQ1UTdSUHVIUnZMMEVxUWJPbkFaMWZFV1JOcHV6dkFxcUMxVzBtYU1vNEpibW5YTGlBVHloNHM5bW1yMXpoSWZhLzJyMFgiLCJtYWMiOiJjZjFiNmEwYWViOTQzZDc2N2YwZDQzMWVjMTQyZjEyMDI5NmFiYWE0ZjdlMzJkNjAxNGVjOTU0OWE1NmUwN2Y4IiwidGFnIjoiIn0%3Dfpestid=7KlDgsQ1KXmHG80Z4LVZcgEjUcAgREiCur_p3PnaVypzdvlYZJRc_wnkuGjuDfDjYiklQQ; _ga_9F3B5VV3T3=GS1.1.1739848225.1.0.1739848225.60.0.0; _ga=GA1.1.1838635158.1739" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:6 [ "fpestid" => null "_ga_9F3B5VV3T3" => null "_ga" => null "wayfindertarget" => null "XSRF-TOKEN" => "pRW4rBEoH99KiqQ628AJpVMj1Zgy78qCmej6CugK" "alphaeurekaselectnet_session" => "F7g5g83WjIMHePa4YHyD7ZhTbCzbk6RTzMECm2rI" ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 18 Feb 2025 03:10:37 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InZ1UkxJUnBYaS9rNFlVNmlBRTBwYlE9PSIsInZhbHVlIjoiSDVvT2hicHdOSHExS0Q3UjZaUTFmT0ZjaUpORFBXdlJ3dDZ2ZEhNQ1BzaDNYZVQvL2wxODVwQTgrcm54SjBnTmdzS1NQdFpHc3hWWGdoN3VMbVJrSVg5ZWZNS0pITTY4S3hRYTdNVW0yUmVJMUNWR2lFNzZSWENIR0ZZZHpJcGQiLCJtYWMiOiI5YWE0MzY5MTUzOWYzNGYyYmVhODBiZjhiNWQ0MzUyNjcwYWM2OTZhN2RlZjRkOTBiYzZkMWI1NDc4ZGUzNjI3IiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 15:10:37 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InZ1UkxJUnBYaS9rNFlVNmlBRTBwYlE9PSIsInZhbHVlIjoiSDVvT2hicHdOSHExS0Q3UjZaUTFmT0ZjaUpORFBXdlJ3dDZ2ZEhNQ1BzaDNYZVQvL2wxODVwQTgrcm54SjBnTmdzS1NQd" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImVGbWFUWCsyNEdKYXVlZ3JINXJPc1E9PSIsInZhbHVlIjoiSVFjWHBScWxaWEROcGhCT3lFMWJsUXJJUDNJQzFGZDY2MklVT2JrKzlMc2tOa3JBcmtIUll4WDFIRW1xQVZJK1Myc0Vtakh0enNoeVIxQWgrR1dWWkNZd2t2ck10U3JlQ2g1SzBhemhXcHBIV09DcXJxMnZaU3phVDlzL0JXaG8iLCJtYWMiOiJhMjFmZGJjMzg0MmYwNzAyM2M0NjZhYThiMmI3ZDI2NTUwY2IxZDg3MDY5YjM5NTVjODVhZWE0ZWExZmRkOWI3IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6ImVGbWFUWCsyNEdKYXVlZ3JINXJPc1E9PSIsInZhbHVlIjoiSVFjWHBScWxaWEROcGhCT3lFMWJsUXJJUDNJQzFGZDY2MklVT2JrKzlMc2tOa3JBcmtIUll4WDF" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InZ1UkxJUnBYaS9rNFlVNmlBRTBwYlE9PSIsInZhbHVlIjoiSDVvT2hicHdOSHExS0Q3UjZaUTFmT0ZjaUpORFBXdlJ3dDZ2ZEhNQ1BzaDNYZVQvL2wxODVwQTgrcm54SjBnTmdzS1NQdFpHc3hWWGdoN3VMbVJrSVg5ZWZNS0pITTY4S3hRYTdNVW0yUmVJMUNWR2lFNzZSWENIR0ZZZHpJcGQiLCJtYWMiOiI5YWE0MzY5MTUzOWYzNGYyYmVhODBiZjhiNWQ0MzUyNjcwYWM2OTZhN2RlZjRkOTBiYzZkMWI1NDc4ZGUzNjI3IiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 15:10:37 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InZ1UkxJUnBYaS9rNFlVNmlBRTBwYlE9PSIsInZhbHVlIjoiSDVvT2hicHdOSHExS0Q3UjZaUTFmT0ZjaUpORFBXdlJ3dDZ2ZEhNQ1BzaDNYZVQvL2wxODVwQTgrcm54SjBnTmdzS1NQd" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImVGbWFUWCsyNEdKYXVlZ3JINXJPc1E9PSIsInZhbHVlIjoiSVFjWHBScWxaWEROcGhCT3lFMWJsUXJJUDNJQzFGZDY2MklVT2JrKzlMc2tOa3JBcmtIUll4WDFIRW1xQVZJK1Myc0Vtakh0enNoeVIxQWgrR1dWWkNZd2t2ck10U3JlQ2g1SzBhemhXcHBIV09DcXJxMnZaU3phVDlzL0JXaG8iLCJtYWMiOiJhMjFmZGJjMzg0MmYwNzAyM2M0NjZhYThiMmI3ZDI2NTUwY2IxZDg3MDY5YjM5NTVjODVhZWE0ZWExZmRkOWI3IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6ImVGbWFUWCsyNEdKYXVlZ3JINXJPc1E9PSIsInZhbHVlIjoiSVFjWHBScWxaWEROcGhCT3lFMWJsUXJJUDNJQzFGZDY2MklVT2JrKzlMc2tOa3JBcmtIUll4WDF" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "pRW4rBEoH99KiqQ628AJpVMj1Zgy78qCmej6CugK" "uc_cart_id" => "6162c8ddadc102cc8e7e93233fe795ec" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14059" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-18 03:10:37GET/chapter/14059112199