Abstract
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a rapid-acting transcription factor. It is present in almost all cell types and is one of the primary responders to several stimuli such as stress, cytokines, radiation, chemotherapeutic drugs, bacterial, and viral antigens. Aberrant regulation and activation of NF-κB have been implicated in several cancers, inflammatory and autoimmune disorders, viral infections, and erroneous immune system development. This chapter summarizes the role of NF-κB activation specifically in hematological malignancies and various strategies developed for its potential pharmacological intervention to abrogate the process of carcinogenesis.
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Cite this chapter as:
Loukik Arora, Frank Arfuso, Alan Prem Kumar, Gautam Sethi ;Role of NF-κB Activation in Multiple Myeloma and Other Hematological Malignancies, Advances in Cancer Signal Transduction and Therapy Recent Advances in Signal Transduction Research and Therapy (2020) 1: 114. https://doi.org/10.2174/9789811458118120010008
DOI https://doi.org/10.2174/9789811458118120010008 |
Print ISSN 2737-4424 |
Publisher Name Bentham Science Publisher |
Online ISSN 2737-4432 |