Frontiers in Cardiovascular Drug Discovery

Volume: 5

The Role of SGLT2i in the Prevention and Treatment of Heart Failure

Author(s): Hasan AlTurki, Ahmed AlTurki, Mark Sherman, Abhinav Sharma and Thao Huynh * .

Pp: 36-64 (29)

DOI: 10.2174/9789811413247120050004

* (Excluding Mailing and Handling)

Abstract

Diabetes mellitus (DM) is an important independent risk factor for incident heart failure (HF). DM is also a prominent prognostic factor for major cardiovascular (CV) adverse events in patients with established HF with reduced (HFrEF) or preserved ejection fraction (HFpEF). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are recently approved drugs for DM treatment. SGLT2i lead to natriuresis and glycosuria with subsequent reductions in blood glucose, intravascular volume, and blood pressure. SGLT2i demonstrated a remarkable relative risk reduction in hospitalization for heart failure in large CV outcome trials of patients with DM. In addition, there was a more modest but also a relevant reduction in CV mortality with empagliflozin. SGLT2i reduce recurrent myocardial infarctions in patients with prior myocardial infarction. SGLT2i were subsequently evaluated in patients with HFrEF, including those without DM. Dapagliflozin was associated with reductions in the primary composite endpoint of worsening heart failure or CV death and each component separately. Considering their remarkable CV benefits and nephroprotection, SGLT2i represent invaluable therapy for the primary and secondary prevention of heart diseases in patients with DM or HFrEF. Ongoing trials may confirm the potential impact of SGTL2i in patients with HFpEF and acutely decompensating HF.


Keywords: Diabetes Mellitus, Heart Failure, SGLT2 Inhibitors.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version201msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[20:34:09] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (103ms)time
  • Application (98.12ms)time
  • 1 x Booting (51.14%)
    103ms
    1 x Application (48.86%)
    98.12ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed28.76ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316312588','',1,1740515649,1740515649) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740515649
      1.27msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316312588','/chapter/14021',1,1740515649,1740515649)
      210μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316312588 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316312588) limit 1
      18.38msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316312588
      • 1: 316312588
      • 2: 316312588
      • 3: 316312588
      • 4: 316312588
      • 5: 316312588
      • 6: 316312588
      • 7: 316312588
      • 8: 316312588
      • 9: 316312588
      • 10: 316312588
      • 11: 316312588
      • 12: 316312588
      • 13: 316312588
      • 14: 316312588
      • 15: 316312588
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '14021' limit 1
      370μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 14021
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '14021' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      940μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 14021
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '14021'
      330μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 14021
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 134 limit 1
      220μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 134
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=134) and se.ebook_id!=134 and v.ebook_status='1'
      850μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=134) and se.ebook_id!=134 and v.ebook_status='1' limit 10 offset 0
      720μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=134)
      390μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=134) limit 10 offset 0
      410μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 2818 and `e`.`is_uploaded` = 1
      480μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 2818
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 134 and ebook_volume_id <> 2818 limit 1
      300μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 134
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '14021' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '2818' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      290μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740515649 and j.to_date >= 1740515649 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2818) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740515649 and j.to_date >= 1740515649 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2818) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740515649 and j.to_date >= 1740515649 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2818)
      690μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740515649 and j.to_date >= 1740515649 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14021) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740515649 and j.to_date >= 1740515649 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14021) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740515649 and j.to_date >= 1740515649 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14021)
      870μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2818 and `b`.`banner_from_date` <= 1740515649 and `b`.`banner_to_date` >= 1740515649 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.43msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2818
      • 3: 1740515649
      • 4: 1740515649
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='381ce0fba76da07a6a97b3dfc24ac47e'
      270μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    3Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        i40CoYD80FSYilo0HgvajcEOia6uMiUqk5xDCSyx
        uc_cart_id
        381ce0fba76da07a6a97b3dfc24ac47e
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14021" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/14021
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IkxQSnpEdzZGQnBVL0piSm5kL1FQT1E9PSIsInZhbHVlIjoiL1pIV1VvS1V1SjVPcHVyYWtQd3dBeG12S1paTXdvMXQ0MWNVTCthWldEYz0iLCJtYWMiOiJlMzJiMzRjMTI1YWZhNWE5ZTk3NTczYjhhY2M2NjFmMTFiYmQ1ZGZjZmNiZDBhYmQ2MWE5MTA3N2M3ZDEwYmZkIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IkxQSnpEdzZGQnBVL0piSm5kL1FQT1E9PSIsInZhbHVlIjoiL1pIV1VvS1V1SjVPcHVyYWtQd3dBeG12S1paTXdvMXQ0MWNVTCthWldEYz0iLCJtYWMiOiJlMzJiMzRjMTI1YWZh" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 20:34:09 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlF2U2ZkaFJlRDdmK1Vlb0NxR25hOVE9PSIsInZhbHVlIjoiRVhIaWdIUms5bW9xZGJtMG5LR09jT0xUdlpsdklqaFZtU2NrNGpwbjZDaHZ6bmc5K2xoSDY4VGxtZFd3aEdtalhjTStUWDRDT256SDFjbUYwVVBUOElaREpaNElHRHNmclRlTnNNWVNPVDc5NkdjV2FuK2crUEt2NTV5RnF4cHkiLCJtYWMiOiJiYTE0MmVlMWZiZTk4ZDFkOWVkYTgyN2E1Njg0Mzc2MmZhMGQyNTBlNjJjYzc4OTg5ZGI0Y2IxYTQ0NThmNWRjIiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 08:34:09 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IlF2U2ZkaFJlRDdmK1Vlb0NxR25hOVE9PSIsInZhbHVlIjoiRVhIaWdIUms5bW9xZGJtMG5LR09jT0xUdlpsdklqaFZtU2NrNGpwbjZDaHZ6bmc5K2xoSDY4VGxtZFd3aEdtalhjTStUW" 1 => "alphaeurekaselectnet_session=eyJpdiI6Imp0SzRSaFJmbkUxZ0FUNW12cEphUUE9PSIsInZhbHVlIjoiV2xPVFJoOTgzdVYyak5RVDdGNmRGN3VoUy8xVStjUWh3RXRRdGVBNnF1MmZxRWJaQ1lwdkRmQjFIY3FSUkpiaWVXcjUzT3hkRCtTdTlwOGw1TW1ycEw3YjRhZmgyT0VLL2k5UUZQMWszbURNd3JYYzdjd2pzRFI5ZllVdlExaFMiLCJtYWMiOiI1MmE0NzliMzI5ODBiNzkyYjY5ODFlYjBiMmNlNjhkMTc3Nzk5NGFlYTZlZGI0N2ZiYmEyYTIzMGNhZmNiMGEwIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Imp0SzRSaFJmbkUxZ0FUNW12cEphUUE9PSIsInZhbHVlIjoiV2xPVFJoOTgzdVYyak5RVDdGNmRGN3VoUy8xVStjUWh3RXRRdGVBNnF1MmZxRWJaQ1lwdkRmQjF" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlF2U2ZkaFJlRDdmK1Vlb0NxR25hOVE9PSIsInZhbHVlIjoiRVhIaWdIUms5bW9xZGJtMG5LR09jT0xUdlpsdklqaFZtU2NrNGpwbjZDaHZ6bmc5K2xoSDY4VGxtZFd3aEdtalhjTStUWDRDT256SDFjbUYwVVBUOElaREpaNElHRHNmclRlTnNNWVNPVDc5NkdjV2FuK2crUEt2NTV5RnF4cHkiLCJtYWMiOiJiYTE0MmVlMWZiZTk4ZDFkOWVkYTgyN2E1Njg0Mzc2MmZhMGQyNTBlNjJjYzc4OTg5ZGI0Y2IxYTQ0NThmNWRjIiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 08:34:09 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IlF2U2ZkaFJlRDdmK1Vlb0NxR25hOVE9PSIsInZhbHVlIjoiRVhIaWdIUms5bW9xZGJtMG5LR09jT0xUdlpsdklqaFZtU2NrNGpwbjZDaHZ6bmc5K2xoSDY4VGxtZFd3aEdtalhjTStUW" 1 => "alphaeurekaselectnet_session=eyJpdiI6Imp0SzRSaFJmbkUxZ0FUNW12cEphUUE9PSIsInZhbHVlIjoiV2xPVFJoOTgzdVYyak5RVDdGNmRGN3VoUy8xVStjUWh3RXRRdGVBNnF1MmZxRWJaQ1lwdkRmQjFIY3FSUkpiaWVXcjUzT3hkRCtTdTlwOGw1TW1ycEw3YjRhZmgyT0VLL2k5UUZQMWszbURNd3JYYzdjd2pzRFI5ZllVdlExaFMiLCJtYWMiOiI1MmE0NzliMzI5ODBiNzkyYjY5ODFlYjBiMmNlNjhkMTc3Nzk5NGFlYTZlZGI0N2ZiYmEyYTIzMGNhZmNiMGEwIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Imp0SzRSaFJmbkUxZ0FUNW12cEphUUE9PSIsInZhbHVlIjoiV2xPVFJoOTgzdVYyak5RVDdGNmRGN3VoUy8xVStjUWh3RXRRdGVBNnF1MmZxRWJaQ1lwdkRmQjF" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "i40CoYD80FSYilo0HgvajcEOia6uMiUqk5xDCSyx" "uc_cart_id" => "381ce0fba76da07a6a97b3dfc24ac47e" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14021" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 20:34:09GET/chapter/14021112195