Recent Progress of Phenazines as Anticancer Agents

Author(s): Hidayat Hussain, Najeeb Ur Rehman, Ghulam Abbas, Khanzadi F. Khattak, Amjad Khan and Ivan R. Green

Pp: 74-96 (23)

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Abstract

Phenazines are nitrogen-containing heterocycles which possess a wide range of biological activities and in particular, cytotoxic effects. Moreover, various phenazines have been prepared having alkyl, amide, carboxylic acid, aldehyde, and pyrano groups. These synthetic phenazines possess significant anticancer effects towards various cancers. On the other hand, only a few natural phenazines have been reported with anticancer effects. This chapter presents a comprehensive overview of the most recent patents related to the phenazines as anticancer agents.

Keywords: Anticancer agent, in vitro, in vivo, natural phenazines, phenazine, synthetic phenazines.

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