Arterial Hypertension in Type 2 Diabetes: Pathogenesis and Treatment

Pp: 160-172 (13)

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Abstract

Diabetes and hypertension are increasing worldwide as an important public health problem. There is a fairly common ground that combines diabetes and hypertension. Especially insulin resistance is very important in this respect. Epidemiological data and randomized clinical trials indicate that appropriate treatment of diabetes and hypertension provides a significant reduction in cardiovascular events. For this reason, it is extremely important that these two diseases be handled separately. ACE inhibitors, ARB blockers, calcium channel blockers and thiazide diuretics are the preferred agents in these patients. For patients with albuminuria, ARB or ACEI should be preferred for renoprotective effects. In patients with resistant hypertension, aldosterone antagonists therapy may be added to present therapy.

Keywords: Aldosterone antagonists therapy, Albuminuria, Arterial hypertension, ACE inhibitors, ARB blockers, Calcium channel blockers, Insulin resistance, Resistant hypertension, Type 2 diabetes, Thiazide diuretics.