Abstract
Aspirin is known to have inter-individual variability in its pharmacodynamic response. Clinical investigators continue their empirical search for the optimum aspirin dose to safely prevent athero-thrombosis. Several patient populations have an accompanied accelerated platelet turnover that is associated with a time-dependent loss of aspirin efficacy. Increasing the dosing frequency has been shown to elicit better and more sustained platelet inhibition compared to a dose increase in these patient populations. This review explores the role of accelerated platelet turnover in aspirin pharmacodynamics and the benefits of multiple daily aspirin dosing.
Keywords: Antiplatelet, Aspirin, Essential Thrombocythemia, High On-Aspirin Platelet Reactivity, Platelet Turnover.
About this chapter
Cite this chapter as:
Nicholas B. Norgard, Priya Jain, Jonathon R. Enriquez ;Should the Argument About Aspirin Dosing be About Frequency Rather the Dose?, Frontiers in Cardiovascular Drug Discovery (2019) 4: 1. https://doi.org/10.2174/9781681083995119040003
DOI https://doi.org/10.2174/9781681083995119040003 |
Print ISSN 2452-3267 |
Publisher Name Bentham Science Publisher |
Online ISSN 1879-6648 |