Reviews in Pharmaceutical & Biomedical Analysis

Control of the Level of Apoptosis by Different Analytical Techniques

Author(s): Małgorzata Starek, Monika Dąbrowska and Jerzy Skuciński

Pp: 108-113 (6)

DOI: 10.2174/978160805190811001010108

* (Excluding Mailing and Handling)

Abstract

The process of programmed cell death, or apoptosis is characterized by distinct morphological and biochemical mechanisms. Inappropriate apoptosis (too little or too much) is a factor in many human conditions including neurodegenerative diseases, autoimmune disorders and many types of cancer. Although many assays for apoptosis detection have been established so far, precise differentiating apoptosis and necrosis in single cells is still a hallenge. In this study we present the most common analytical techniques for the control of the level of apoptosis.

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      • 11. app/Models/ContentAccess.php:647
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51271243 and j.to_ip >=51271243 )) and ((j.from_date <= 1739848350 and j.to_date >= 1739848350 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1200) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51271243 and j.to_ip >=51271243 )) and ((j.from_date <= 1739848350 and j.to_date >= 1739848350 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1200) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51271243 and j.to_ip >=51271243 )) and ((j.from_date <= 1739848350 and j.to_date >= 1739848350 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1200)
      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 876 and `b`.`banner_from_date` <= 1739848350 and `b`.`banner_to_date` >= 1739848350 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.2msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 876
      • 3: 1739848350
      • 4: 1739848350
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='9a279d716bfc8bdc85ffc9251b889785'
      240μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        zRxPNWoOJSCAFxnz0NSWvOfSxb1CFi59uTYELM9m
        uc_cart_id
        9a279d716bfc8bdc85ffc9251b889785
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1200" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/1200
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IjliNWUxMlRwRnJZdXlueUxMYXFEMVE9PSIsInZhbHVlIjoiZEJDZ1JZbGxDRkM4enFUdWZHdWJSM0lqMEZXTWJGK2NPYmFPYkNRYWFFbz0iLCJtYWMiOiI2OTg4MzkyODAxNTQwMmRiZDI2MzJkZjk0ZjkzMjRmYmMxZGNhZDcyNjRlMjA2YjRhOWQ2NGU2MDc5MjAwZTg0IiwidGFnIjoiIn0%3D; XSRF-TOKEN=eyJpdiI6IlNWTzBnYkV6RFkzQnRCanNxSjdvREE9PSIsInZhbHVlIjoibmQ0eUlWbHdsRTFrWS9aT3A4dVNFczIxTHlZVitkYUhObTRvVnBhVitvTno0TG44eENmcWRNTW8zVkxRYzg4cVF5b1BjZ01FZmptVlkwVGJRb3dDNHM3aWF4Z2wyaWdWVExrcHgxL1NZdkkyQWlWTjNuc25yMU9NRVNmd05iZGkiLCJtYWMiOiI2YzNmNTI1Yzk1MjU3YjJhZmMyNmM4N2Y5YTEyZmU5OWM0ODQzZDA5OTg0MmNkNjIxY2JmMTNmMTlmNDFkZmEyIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6InQyZnduM3A1QnRuYldLZG02TXo2cmc9PSIsInZhbHVlIjoib2diUWl4dHY5RHBiajdPb2RDcndhN0sza1VYT1RIc1VCelBYTE0yU09XT2ZTTTFKZnUzSUlqRWtCbm80MmhXa3c3d3dGWEVqeW0wbG1icElmQ1RjNzRNcUxKVHJMVGhjdUkyTzlNa05yS1JGL2trejN3QTJITHVvUnozb0YzSXAiLCJtYWMiOiJjMGNhZjNlYjMwNWVlNjJkMzMxZjI1YmY0NDAwZWYwOGRiYmUyMDhhMGUwNGVjMDUzMTkzZWJjNjlhYTFiYWYyIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IjliNWUxMlRwRnJZdXlueUxMYXFEMVE9PSIsInZhbHVlIjoiZEJDZ1JZbGxDRkM4enFUdWZHdWJSM0lqMEZXTWJGK2NPYmFPYkNRYWFFbz0iLCJtYWMiOiI2OTg4MzkyODAxNTQw" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
        0 of 0
        array:5 [ "_token" => "zRxPNWoOJSCAFxnz0NSWvOfSxb1CFi59uTYELM9m" "uc_cart_id" => "9a279d716bfc8bdc85ffc9251b889785" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1200" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-18 03:12:30GET/chapter/1200112193