Tropical Diseases: An Overview of Major Diseases Occurring in the Americas

Biological Database and Bioinformatics Tools in Tropical Disease Research

Author(s): Valdir Queiroz Balbino, Manuela Barbosa Rodrigues de Souza, Sergio Paiva de Sa Leitao Junior, Raul Maia Falcao and Marcus Vinicius de Aragao Batista

Pp: 489-502 (14)

DOI: 10.2174/9781681085876117010023

* (Excluding Mailing and Handling)

Abstract

Bioinformatics is an interdisciplinary field that combines elements of the areas of biological sciences and computing, which has become fundamental in health science research. Bioinformatics is based on the development and application of computational tools to extract knowledge from biological data and to solve real-world problems in human health, which contributes to the diagnosis and control of infectious diseases. Much of the biological information is obtained through comparison of genomic sequences. Currently Next-Generation-Sequencing provides a wide genetic database which overcomes Sanger sequencing. Nitrogenous bases are identified by signals emitted for each fragment of DNA strand that it occurs through large massive reactions. In this context, sequence alignment methods are relevant. Evolutionary and functional patterns could be extracted from multiple sequence alignments, which could point to molecular markers, receptors, or targets that could be important to develop control measures of several diseases. Bioinformatics could also be applied in proteomic and transcriptomic studies, increasing the knowledge at the molecular biology level of protozoa and transmission vectors. Therefore, Bioinformatics tools are relevant to gather information about Neglected Tropical Diseases, and so, novel control methods could be tested and developed.


Keywords: Bioinformatics, Neglected Tropical Diseases, Next-Generation- Sequencing, Sequence Analysis.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version311msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[20:28:56] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (174ms)time
  • Application (137ms)time
  • 1 x Booting (56.06%)
    174ms
    1 x Application (43.94%)
    137ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed37.54ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316296980','',1,1740515336,1740515336) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740515336
      1.3msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316296980','/chapter/11869',1,1740515336,1740515336)
      240μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316296980 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316296980) limit 1
      20.32msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316296980
      • 1: 316296980
      • 2: 316296980
      • 3: 316296980
      • 4: 316296980
      • 5: 316296980
      • 6: 316296980
      • 7: 316296980
      • 8: 316296980
      • 9: 316296980
      • 10: 316296980
      • 11: 316296980
      • 12: 316296980
      • 13: 316296980
      • 14: 316296980
      • 15: 316296980
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '11869' limit 1
      450μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 11869
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '11869' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.92msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 11869
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '11869'
      400μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 11869
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 687 limit 1
      330μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 687
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=687) and se.ebook_id!=687 and v.ebook_status='1'
      4.02msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=687) and se.ebook_id!=687 and v.ebook_status='1' limit 10 offset 0
      1.1msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=687)
      640μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=687) limit 10 offset 0
      650μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 2421 and `e`.`is_uploaded` = 1
      1.05msalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 2421
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 687 and ebook_volume_id <> 2421 limit 1
      390μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 687
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '11869' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      430μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '2421' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      440μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316296980 and j.to_ip >=316296980 )) and ((j.from_date <= 1740515336 and j.to_date >= 1740515336 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2421) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316296980 and j.to_ip >=316296980 )) and ((j.from_date <= 1740515336 and j.to_date >= 1740515336 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2421) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316296980 and j.to_ip >=316296980 )) and ((j.from_date <= 1740515336 and j.to_date >= 1740515336 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2421)
      960μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316296980 and j.to_ip >=316296980 )) and ((j.from_date <= 1740515336 and j.to_date >= 1740515336 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11869) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316296980 and j.to_ip >=316296980 )) and ((j.from_date <= 1740515336 and j.to_date >= 1740515336 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11869) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316296980 and j.to_ip >=316296980 )) and ((j.from_date <= 1740515336 and j.to_date >= 1740515336 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11869)
      990μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2421 and `b`.`banner_from_date` <= 1740515336 and `b`.`banner_to_date` >= 1740515336 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.54msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2421
      • 3: 1740515336
      • 4: 1740515336
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='0a50842ded87d7f9efff077d3a5584f8'
      370μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    4Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        aKCIwvYBqMOag9YebWXu050f72dOev1oR2lQtqEq
        uc_cart_id
        0a50842ded87d7f9efff077d3a5584f8
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/11869" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/11869
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6ImZrQjZhclhPZE1GSGpLRTZsblFGYXc9PSIsInZhbHVlIjoiMmsyaVJXNEEwcVI4SDBZRVRMZ05mbnRvd1VnaVBUR1RhdGcwMFdtZ3FtST0iLCJtYWMiOiI2OGFlYzRjMDAwOWU2NDM2ODNiMWJiMDBmYWFkOGNmYzg2Y2E5YzY0MjA1YmM4ZGMwYTI0MjQyZmU2NzE1YzM2IiwidGFnIjoiIn0%3D; XSRF-TOKEN=eyJpdiI6Im5ITWI1a1ZaSVNjV09IVmZncW0xZlE9PSIsInZhbHVlIjoiUmVhYnpLRE5SMVFIQ0kyZWlSREVBRW91MFB3N0x2ZXVaVDYzTnhwV3VQa25KUHVBMDZHcmQrTllIOGtld0ZXUEQyNGMzbFBqUm9NWW9oUnhzNjZkOGNzV3VRR2NqY2JaSFFSKzR4V1d1MFVSaEhrMlRxMXhoWVlJMVBUN2xTZTkiLCJtYWMiOiI0ZWFmMjY5NDg5NzE1NzEwMGVlNzdhZTg4NmU3YTA2NjkxN2VjNzdjMzY1NmYzNWNmYzM0YjUyNWE2YTQ0Njg0IiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6IkJlYys3YURZbXJNZnZNL2hrTEJUREE9PSIsInZhbHVlIjoiU3dsbWE5bGc3M3pMU2lNelNxS1N0ekFNZ3RSSTJHTlN1cmovY2k3K3Q4MlNTK2NTV014L0R1VmJENWNHQ2pRS09nc2ZMbXhEODVMU1piTmxNZE9nZFhLQ3piQlJOWGNUSS83ZHJvM2ZBMk40WFJpTnVIWEFySzlpK1p4R3c0aFEiLCJtYWMiOiJmMTJmYmE1ZmM3OTJkYTQ2Y2I0OWQyZWE0YjA1ZTJjNDI3OGQxYjEzZWY2ZGUzZjcyZDk1ZTFmNTE2MGViMzdjIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6ImZrQjZhclhPZE1GSGpLRTZsblFGYXc9PSIsInZhbHVlIjoiMmsyaVJXNEEwcVI4SDBZRVRMZ05mbnRvd1VnaVBUR1RhdGcwMFdtZ3FtST0iLCJtYWMiOiI2OGFlYzRjMDAwOWU2" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:3 [ "wayfindertarget" => null "XSRF-TOKEN" => "aKCIwvYBqMOag9YebWXu050f72dOev1oR2lQtqEq" "alphaeurekaselectnet_session" => "s54RYkcv4EBDlIPJqKnoLWPHXhu7lKXoMIwseXJ3" ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 20:28:56 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InpFbG1jU3hxUXRVa0hNZWZkYXVNTmc9PSIsInZhbHVlIjoiOStDSFR6eHRCczJ2Mm9QaFBOMW50YnBjaWJqWmdueCtja1ExUzI1SG5DcnJhSkd4SUtHdTlVT3d0UWRMcnJ4eHQ4TEdRMjR4TFBpaWNWVnk0Rm9YcklvZzkxUHZ0MVdqeVRRSm5KSy9zZ0N4S3JzZUlNK054bXRCRndEbkJQSysiLCJtYWMiOiI1NjIyYjkxNjYxYjI4MjkxYWJmY2ZlNGI5NDAzNTA3NDQyMmJiM2ZkYWU0NDJkNzljMDhmN2YwYTYxODkyMzNiIiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 08:28:56 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InpFbG1jU3hxUXRVa0hNZWZkYXVNTmc9PSIsInZhbHVlIjoiOStDSFR6eHRCczJ2Mm9QaFBOMW50YnBjaWJqWmdueCtja1ExUzI1SG5DcnJhSkd4SUtHdTlVT3d0UWRMcnJ4eHQ4TEdRM" 1 => "alphaeurekaselectnet_session=eyJpdiI6InJ6a1h1eXFWd0k1WjhjSnRJaUU3Ync9PSIsInZhbHVlIjoidG5Sc3l1MExZNncxSEYzQUZ5R2ZGd2RFbXRoemxMOG1BNnkrL2xyM0JsNUw0bUVWMDMzSjJFMC9uRXNuV0NIMmZDSE5wUVc2bGxTM1lreEJBQ3g1NUdaQk5OaEx6T0hHelhVV01vSXJLOUR0cFZFMVdPL0JrZHZENTF5SWVBcjYiLCJtYWMiOiIzMmNkNDJlYzQxMjA0ZGUyZTAwNGYxNTlkMTI4ZTQ2NTQzMTk4OTNlNjgxYzI2ZWRmZWE2MTAyNjkyMzcyN2I4IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6InJ6a1h1eXFWd0k1WjhjSnRJaUU3Ync9PSIsInZhbHVlIjoidG5Sc3l1MExZNncxSEYzQUZ5R2ZGd2RFbXRoemxMOG1BNnkrL2xyM0JsNUw0bUVWMDMzSjJFMC9" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InpFbG1jU3hxUXRVa0hNZWZkYXVNTmc9PSIsInZhbHVlIjoiOStDSFR6eHRCczJ2Mm9QaFBOMW50YnBjaWJqWmdueCtja1ExUzI1SG5DcnJhSkd4SUtHdTlVT3d0UWRMcnJ4eHQ4TEdRMjR4TFBpaWNWVnk0Rm9YcklvZzkxUHZ0MVdqeVRRSm5KSy9zZ0N4S3JzZUlNK054bXRCRndEbkJQSysiLCJtYWMiOiI1NjIyYjkxNjYxYjI4MjkxYWJmY2ZlNGI5NDAzNTA3NDQyMmJiM2ZkYWU0NDJkNzljMDhmN2YwYTYxODkyMzNiIiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 08:28:56 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InpFbG1jU3hxUXRVa0hNZWZkYXVNTmc9PSIsInZhbHVlIjoiOStDSFR6eHRCczJ2Mm9QaFBOMW50YnBjaWJqWmdueCtja1ExUzI1SG5DcnJhSkd4SUtHdTlVT3d0UWRMcnJ4eHQ4TEdRM" 1 => "alphaeurekaselectnet_session=eyJpdiI6InJ6a1h1eXFWd0k1WjhjSnRJaUU3Ync9PSIsInZhbHVlIjoidG5Sc3l1MExZNncxSEYzQUZ5R2ZGd2RFbXRoemxMOG1BNnkrL2xyM0JsNUw0bUVWMDMzSjJFMC9uRXNuV0NIMmZDSE5wUVc2bGxTM1lreEJBQ3g1NUdaQk5OaEx6T0hHelhVV01vSXJLOUR0cFZFMVdPL0JrZHZENTF5SWVBcjYiLCJtYWMiOiIzMmNkNDJlYzQxMjA0ZGUyZTAwNGYxNTlkMTI4ZTQ2NTQzMTk4OTNlNjgxYzI2ZWRmZWE2MTAyNjkyMzcyN2I4IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6InJ6a1h1eXFWd0k1WjhjSnRJaUU3Ync9PSIsInZhbHVlIjoidG5Sc3l1MExZNncxSEYzQUZ5R2ZGd2RFbXRoemxMOG1BNnkrL2xyM0JsNUw0bUVWMDMzSjJFMC9" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "aKCIwvYBqMOag9YebWXu050f72dOev1oR2lQtqEq" "uc_cart_id" => "0a50842ded87d7f9efff077d3a5584f8" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/11869" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 20:28:56GET/chapter/11869112196