Abstract
The human immunodeficiency virus (HIV) infection into the brain induces neurotoxicity and neuropathology which are collectively termed as the neuroAIDS. Brain delivery of therapeutic molecules continues to be the greatest challenge, primarily because of the tightly-junctioned blood-brain barrier (BBB). Several nanovehicles are under intensive examination for delivering drugs across the BBB. Magnetic nanoparticles (MNPs) possess advantages over their counterparts because of their potential utilization for non-invasive brain targeting using external magnetic force. MNPs can be physicochemically modulated for engineering smart drug delivery carrier as well. Nonetheless, rigorous research is required to fix associated shortcomings of MNPs before their real-time application.
Keywords: Blood-Brain Barrier, HIV, Magnetic Nanocarriers, NeuroAIDS, Neuropathogenesis, Synaptic plasticity.
About this chapter
Cite this chapter as:
Vidya Sagar, Arti Vashist, Madhavan Nair ;Potential Magnetic Nanotherapeutics for Management of neuroAIDS, Frontiers in Clinical Drug Research: HIV (2019) 4: 34. https://doi.org/10.2174/9781681085265117040004
DOI https://doi.org/10.2174/9781681085265117040004 |
Print ISSN 2468-0397 |
Publisher Name Bentham Science Publisher |
Online ISSN 2352-5916 |