Abstract
Entry of HIV-1 into targeted host cells is a highly ordered multistage process involving first-receptor attachment, co-receptor binding, and membrane fusion. In this chapter, I will present an overview of progress on HIV-1 entry inhibitors with a focus on chemokine receptor-based antagonists. This chapter, at first, will describe the working mechanisms of chemokine receptors, HIV-1 co-receptors CCR5 and CXCR4, during the replication procedure. Then, the antagonists-based on different mechanisms will be presented in detail. At last, it will summarize and explain the distinct promising entry inhibitors based on co-receptors-interacting proteins, which is inspired by our current work.
Keywords: AIDS, CCR5, Chemokine receptor, Co-receptor, CXCR4, Entry inhibitor, HIV.
About this chapter
Cite this chapter as:
Yi-Qun Kuang ;The Development and Clinical Progress on Chemokine Receptor-Based HIV Entry Inhibitors, Frontiers in Clinical Drug Research: HIV (2019) 4: 105. https://doi.org/10.2174/9781681085265119040006
DOI https://doi.org/10.2174/9781681085265119040006 |
Print ISSN 2468-0397 |
Publisher Name Bentham Science Publisher |
Online ISSN 2352-5916 |