Frontiers in Neurosurgery

Volume: 4

Experimental Craniopharyngioma Research

Author(s): Guang-long Huang and Jie Zhou

Pp: 88-97 (10)

DOI: 10.2174/9781681085326117040007

* (Excluding Mailing and Handling)

Abstract

Craniopharyngioma, an intracranial, extra-axial, epithelial tumor of the sellar or parasellar region that grows along the craniopharyngeal duct, was established in 1904 as a distinct tumor type by the Austrian neuropathologist Jakob Erdheim. Though classified as a Grade I tumor by the World Health Organization, craniopharyngioma can cause significant morbidity through its intimate involvement with and mass effects on surrounding critical structures, including the hypothalamus, pituitary gland, and optic chiasm, and its tendency to recur even after successful therapy. Many extensive and in-depth studies of craniopharyngioma have been conducted; however, during the past century, studies of the genetic and molecular basis of the two major craniopharyngioma subtypes (adamantinomatous and squamous papillary) have been limited because of the benign histology, epidemiological rarity (relative to malignant tumors), and lack of a tumor research platform and technical conditions associated with these lesions. Therefore, consensus remains lacking with respect to the etiology, pathological features, pathogenesis, and biological characteristics of these formidable neoplasms. In this chapter, we reviewed experimental craniopharyngioma research.


Keywords: Craniopharyngioma, EMT, Experimental research, Inflammation, mice model.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51137665 and j.to_ip >=51137665 )) and ((j.from_date <= 1740775941 and j.to_date >= 1740775941 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11656) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51137665 and j.to_ip >=51137665 )) and ((j.from_date <= 1740775941 and j.to_date >= 1740775941 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11656) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51137665 and j.to_ip >=51137665 )) and ((j.from_date <= 1740775941 and j.to_date >= 1740775941 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11656)
      1.44msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2404 and `b`.`banner_from_date` <= 1740775941 and `b`.`banner_to_date` >= 1740775941 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.67msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2404
      • 3: 1740775941
      • 4: 1740775941
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='ad660fcaa57335268ef6ccbf4d432aea'
      380μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:291
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    5Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        dhNxxjI8yu2OhH2yb7nMx0p054ZGGxFh8qaE514z
        uc_cart_id
        ad660fcaa57335268ef6ccbf4d432aea
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        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
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        status_code
        200
        
        status_text
        OK
        format
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        content_type
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        request_query
        []
        
        request_request
        []
        
        request_headers
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-28 20:52:21GET/chapter/11656112197