Frontiers in Stem Cell and Regenerative Medicine Research

Volume: 7

Magnetic Nanoparticles in Regenerative Medicine - Current Role and Future Perspectives

Author(s): Luminita Labusca, Dumitru-Daniel Herea, Oana Dragos-Pinzaru, Horia Chiriac and Nicoleta Lupu

Pp: 163-239 (77)

DOI: 10.2174/9781681085524117070008

* (Excluding Mailing and Handling)

Abstract

Together with the regenerative medicine (RM) and personalized therapies, nanomedicine represents one of the fields of advanced therapies that are sought to drastically revolutionize heath care and significantly improve quality of life at a global level. Based on nanoscience and nanotechnology, nanomedicine methods have already entered the field of clinical application by means of drug delivery solutions and contrast agents for medical Imagistics while nano-based carrier and nano-biosensors are in different stages of testing for clinical applications. The use of nano-scaled materials, particularly of magnetic nanoparticles (MNPs) has evolved as an increasing field of research in life sciences. Both physical and chemical properties of MNPs are relevant for a wide scale of medical application for the diagnostic, prevention and treatment of various diseases. Iron oxide based MNPs are being explored as agents for cellular magnetic separation magnetic resonance imaging (MRI) or drug delivery. MNPs have been proposed as tracking agents for cell delivery in various cellular therapy scenarios. In the context of multimodal therapies for the treatment of solid malignancies, the use of hyperthermia (HT) as an adjuvant therapy can be traced back to the beginning of the 20th century. During the last decades, different forms of HT have been used in combination with radio- or chemotherapy. However, local and systemic side effects on healthy tissues are limiting its application. MNPs-based HT treatment of malignancies has gained significant interest in the recent years as they are able to deliver local targeted HT of improved precision compared to the traditional methods. MNPs are tested as modalities to increase efficiency of scaffold fabrication, scaffold functionalization and cell patterning in tissue engineering. MNPs bound to cells can be used to deliver highly controllable mechanical stimulation while within a magnetic field, improving stem cell differentiation especially to musculoskeletal lineages. Cells that have incorporated MNPs or magnetic cationic liposomes can be manipulated to construct three dimensional structures for scaffold free tissue engineering strategies such as cell sheet fabrication, spheroid formation or cell clustering. Placed at the frontier between nanomedicine, tissue regeneration and cell therapy, this chapter describes the current applications of MNPs for the design of advanced therapies as well as future avenues for research and development in this increasingly impacting field.


Keywords: Nanomedicine, Magnetic nanoparticles, Regenerative medicine, Stem cell therapy, Tissue engineering, Nanotoxicity, Nanoparticle internalization, Magnetic actuation, Cellular imaging, Cell tagging, Magnetic mediated drug delivery, Magnetic scaffolds, Magnetofection.

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59799503 and j.to_ip >=59799503 )) and ((j.from_date <= 1740776236 and j.to_date >= 1740776236 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11087) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59799503 and j.to_ip >=59799503 )) and ((j.from_date <= 1740776236 and j.to_date >= 1740776236 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11087) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59799503 and j.to_ip >=59799503 )) and ((j.from_date <= 1740776236 and j.to_date >= 1740776236 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11087)
      890μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2270 and `b`.`banner_from_date` <= 1740776236 and `b`.`banner_to_date` >= 1740776236 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      16.52msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2270
      • 3: 1740776236
      • 4: 1740776236
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='6018ba2eb5252faebcc1d251fb083c32'
      310μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:291
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    13Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        UC1Rde7GnfkPQeLvkcCksOOcJbklcgl9zKRT7T2r
        uc_cart_id
        6018ba2eb5252faebcc1d251fb083c32
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/11087" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/11087
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Ikd6MXJoVEZYc3d4cTB6Z3I2UVM1ZVE9PSIsInZhbHVlIjoiVFNGcHpkYzJzckNkdER3Q3Z3dys3MkhZcnV6cXl0TXo3Uko0VFlDSkh5OD0iLCJtYWMiOiIyYzExNjk1OGRjY2VkYjI3OGU3MTkxMWEyMzZjNjdkYzEyNjAwZTI1MjllZjE5YjkzN2RjZTc2ZjhhNzBkZWQ1IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Ikd6MXJoVEZYc3d4cTB6Z3I2UVM1ZVE9PSIsInZhbHVlIjoiVFNGcHpkYzJzckNkdER3Q3Z3dys3MkhZcnV6cXl0TXo3Uko0VFlDSkh5OD0iLCJtYWMiOiIyYzExNjk1OGRjY2Vk" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Fri, 28 Feb 2025 20:57:16 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImZ3RDUyaE9sVnJqUUhtUU1rVStOc0E9PSIsInZhbHVlIjoiUWlVanBVbjFzczl5WUoyTFF0aXN3azlzQUpzQ28rSWthOEgxc2M3NEtzLzZscSt4b1N6WGZnTHhuNUVoTEhHelJ4ZmFXNlFJL2plaGkvTHdVWEN2WXRDV1RvVWlpNVVTcm8wWU0xbEREWnJiY0Vmc2JvWTVua0czYmxCWmZ4bUoiLCJtYWMiOiI1ZTk3YTI0NTViNTNkMzQ3YzllN2I2MjlmOTUxNGIwZGUxYWRlMjRlYjk3OGFjYjA5NjhiMDk1MmNiOTNiZWViIiwidGFnIjoiIn0%3D; expires=Mon, 03 Mar 2025 08:57:16 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImZ3RDUyaE9sVnJqUUhtUU1rVStOc0E9PSIsInZhbHVlIjoiUWlVanBVbjFzczl5WUoyTFF0aXN3azlzQUpzQ28rSWthOEgxc2M3NEtzLzZscSt4b1N6WGZnTHhuNUVoTEhHelJ4ZmFXN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjFnNmVHNVFDZEIyRm9JUkhld0ZOSUE9PSIsInZhbHVlIjoiaVplTmlUSXNLQkprU1FSR1hJNlI4Q1Vqai9WT0I5VDhtdDlLamgzeUJLRXZ2T21OSXF4Yzh5N0NwcUhOdU9DT2xmSzRVMjdEUFJyNGtJQzNCMHpSSHc2WVZoWndLUVBSNWJYeXpRdk5nQ3hJNE9BZkg0aUUvWUUrc0ZFOU9VZVAiLCJtYWMiOiI1MGZmYjM1ODQ4MjZkZDI2NDA5ODdiZDlhMjRmNGU0YTI1MDEzNWQwZmI3M2UzMjYxMDk5OGE3MTEwZjY5OWVlIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjFnNmVHNVFDZEIyRm9JUkhld0ZOSUE9PSIsInZhbHVlIjoiaVplTmlUSXNLQkprU1FSR1hJNlI4Q1Vqai9WT0I5VDhtdDlLamgzeUJLRXZ2T21OSXF4Yzh5N0N" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImZ3RDUyaE9sVnJqUUhtUU1rVStOc0E9PSIsInZhbHVlIjoiUWlVanBVbjFzczl5WUoyTFF0aXN3azlzQUpzQ28rSWthOEgxc2M3NEtzLzZscSt4b1N6WGZnTHhuNUVoTEhHelJ4ZmFXNlFJL2plaGkvTHdVWEN2WXRDV1RvVWlpNVVTcm8wWU0xbEREWnJiY0Vmc2JvWTVua0czYmxCWmZ4bUoiLCJtYWMiOiI1ZTk3YTI0NTViNTNkMzQ3YzllN2I2MjlmOTUxNGIwZGUxYWRlMjRlYjk3OGFjYjA5NjhiMDk1MmNiOTNiZWViIiwidGFnIjoiIn0%3D; expires=Mon, 03-Mar-2025 08:57:16 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImZ3RDUyaE9sVnJqUUhtUU1rVStOc0E9PSIsInZhbHVlIjoiUWlVanBVbjFzczl5WUoyTFF0aXN3azlzQUpzQ28rSWthOEgxc2M3NEtzLzZscSt4b1N6WGZnTHhuNUVoTEhHelJ4ZmFXN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjFnNmVHNVFDZEIyRm9JUkhld0ZOSUE9PSIsInZhbHVlIjoiaVplTmlUSXNLQkprU1FSR1hJNlI4Q1Vqai9WT0I5VDhtdDlLamgzeUJLRXZ2T21OSXF4Yzh5N0NwcUhOdU9DT2xmSzRVMjdEUFJyNGtJQzNCMHpSSHc2WVZoWndLUVBSNWJYeXpRdk5nQ3hJNE9BZkg0aUUvWUUrc0ZFOU9VZVAiLCJtYWMiOiI1MGZmYjM1ODQ4MjZkZDI2NDA5ODdiZDlhMjRmNGU0YTI1MDEzNWQwZmI3M2UzMjYxMDk5OGE3MTEwZjY5OWVlIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjFnNmVHNVFDZEIyRm9JUkhld0ZOSUE9PSIsInZhbHVlIjoiaVplTmlUSXNLQkprU1FSR1hJNlI4Q1Vqai9WT0I5VDhtdDlLamgzeUJLRXZ2T21OSXF4Yzh5N0N" ] ]
        session_attributes
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        array:5 [ "_token" => "UC1Rde7GnfkPQeLvkcCksOOcJbklcgl9zKRT7T2r" "uc_cart_id" => "6018ba2eb5252faebcc1d251fb083c32" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/11087" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-28 20:57:16GET/chapter/110871121915