Abstract
Orofacial clefts are among the commonest malformations affecting mankind; even though most cases of orofacial clefts are non-syndromic, they may also manifest concomitantly with a wide array of syndromes. These syndromes with orofacial clefts often also cause diverse tooth abnormalities; knowledge on these peculiarities is fundamental for professionals to allow proper dental care for affected individuals.
Keywords: Dental care, Ectrodactyly, Ectodermal dysplasia, and cleft-lip-palate syndrome, Holoprosencephaly, Orofacial cleft, Orofaciodigital syndromes, Rapp- Hodgkin syndrome, Pierre Robin syndrome, Richieri Costa Pereira syndrome, Tooth abnormalities, Van der Woude syndrome, 22q11 deletion syndrome.