Abstract
Haemophilia as other complex diseases deserves several peculiar orthopaedic conditions that may not be classified in specific routinary categories. A multidisciplinary approach and a full information of the patients may be useful to treat such usually difficult cases. An overview of unusual clinical settings regarding joints, bones, and muscles are reported. Finally, a brief summary of the gene therapies and novel approaches is presented.
Keywords: Antithrombin, Adeno-associated virus, Bilateral joint replacement, Gene therapy, Haemophilia, Haematoma, Iliopsoas, Periarticular ossifications, Pseudotumours, Simultaneous bilateral joint replacement, Surgical treatment.