Anti-Obesity Drug Discovery and Development

Volume: 3

Proteomics in the Characterization of New Target Therapies in Pediatric Obesity Treatment

Author(s): Gillian E. Walker, Marilisa De Feudis, Marta Roccio, Gianni Bona and Flavia Prodam

Pp: 80-148 (69)

DOI: 10.2174/9781681081878117030005

* (Excluding Mailing and Handling)

Abstract

Adipose tissue (AT) with a central role in body weight homeostasis, inflammation and insulin resistance, is a highly orchestrated tissue involving receptor and second messenger pathways with steps and passes that influence hyperplasia, hypertrophy, adipocyte differentiation, turnover, lipolysis, free-fatty acid (FFA) metabolism, lipogenesis and the secretome profile. Due to the limitations of the classical molecular biological methods only pieces of the puzzle have been studied, with studies failing to consider the global, time-resolved changes that are evident in this highly plastic organ. “Proteomics”, first coined in 1995 is a large-scale characterization of the entire protein profile of a cell line, tissue, or organism not only from the perspective of expression but also post-translational modifications. As such proteomic technologies offer powerful tools for identifying key components of the adipose proteome, which may contribute to the pathogenesis of adipose tissue dysfunction in obesity. In this review, we plan to address the recent advances in the proteomic characterization of pediatric obesity, in particular the newly identified proteins that potentially play relevant roles and offer targets for novel therapies.


Keywords: Adipose tissue, Biomarkers, Circulation, Lifestyle, Obesity, Pediatric, Proteomic, Secretome, Therapy.

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      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314549955 and j.to_ip >=314549955 )) and ((j.from_date <= 1740496361 and j.to_date >= 1740496361 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 10419) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314549955 and j.to_ip >=314549955 )) and ((j.from_date <= 1740496361 and j.to_date >= 1740496361 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 10419) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314549955 and j.to_ip >=314549955 )) and ((j.from_date <= 1740496361 and j.to_date >= 1740496361 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 10419)
      660μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2228 and `b`.`banner_from_date` <= 1740496361 and `b`.`banner_to_date` >= 1740496361 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.09msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2228
      • 3: 1740496361
      • 4: 1740496361
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='2149c089bdf0979913295a11bf94d87c'
      220μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    9Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        8W2FvSL0vB5ihLXhqoP1vVcKKKcIbJYPMf8rEuh7
        uc_cart_id
        2149c089bdf0979913295a11bf94d87c
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/10419" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/10419
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IkpkVFk2Y3BDa28ybG9wUVQzc0lrVmc9PSIsInZhbHVlIjoiMUhCZDR1QTdDM0NXV2dtT2FheGlhWFpsbFNiSk9HZm1qQWxYaDZ1R0xkZz0iLCJtYWMiOiJjYTJmYzhkNjM5MzNmOTkzY2QzY2MxM2ZlZWZkODdiNjZiYjQ2YWM2MjBkZWFkMjE5NDhlYjk1ZDgyNGVkZTAzIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IkpkVFk2Y3BDa28ybG9wUVQzc0lrVmc9PSIsInZhbHVlIjoiMUhCZDR1QTdDM0NXV2dtT2FheGlhWFpsbFNiSk9HZm1qQWxYaDZ1R0xkZz0iLCJtYWMiOiJjYTJmYzhkNjM5MzNm" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 15:12:41 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlhQbDJiMUNsQy9US3ZyUGhFQmVydlE9PSIsInZhbHVlIjoicUpwdDV0cWJnVWtNdllabSs0Q0JuWEdDQ2lTRWVxaWFON2NWeVhuM3dMZ0d2ZDJlaUczaHNkemUvRms2aHJRNDA2V21pNjlaMlJHVEZtMkRFYmtESHBCdHJVdHk2bXZ1S3RmNDNqNklHNDM3aUlxRjBlMjV0aXY5ZTVpd3g1RmIiLCJtYWMiOiJkNjMxNWM0MDM0ZGU3ZDZmZDU3ODE5NTAwMzM3ZDFlMDY0NmNlNDExNzUwNTVhOWVkMDgxZmVhZjdhMWQ5NjNmIiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 03:12:41 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IlhQbDJiMUNsQy9US3ZyUGhFQmVydlE9PSIsInZhbHVlIjoicUpwdDV0cWJnVWtNdllabSs0Q0JuWEdDQ2lTRWVxaWFON2NWeVhuM3dMZ0d2ZDJlaUczaHNkemUvRms2aHJRNDA2V21pN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjJtSVVOUUFuV0FhcGJtODJlNVV3SHc9PSIsInZhbHVlIjoib2REdmxJaXdwbitMMVZZekxzc1liRFJpNWZmaVp6dHJLQ1IvenN4bEVtYTZ1WnJySVlXMDFRc2taVkdEaTRuZXNraE5VRTQ2dmN5QjBOZkF1ckRMSTB0NWJiV0g2dndQbUM3b09wWUVianhOWnZVc2FTQmVCRXlNTHdPUW9lTmYiLCJtYWMiOiIwNWI2MzY4YmMyNWU5ZTJjNDVkNDFjYzhmMzJjZTEwNGFjNGMzNGE1OThmZDA2ZjFkNTE5MmJiN2NiNjJjOWZkIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjJtSVVOUUFuV0FhcGJtODJlNVV3SHc9PSIsInZhbHVlIjoib2REdmxJaXdwbitMMVZZekxzc1liRFJpNWZmaVp6dHJLQ1IvenN4bEVtYTZ1WnJySVlXMDFRc2t" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlhQbDJiMUNsQy9US3ZyUGhFQmVydlE9PSIsInZhbHVlIjoicUpwdDV0cWJnVWtNdllabSs0Q0JuWEdDQ2lTRWVxaWFON2NWeVhuM3dMZ0d2ZDJlaUczaHNkemUvRms2aHJRNDA2V21pNjlaMlJHVEZtMkRFYmtESHBCdHJVdHk2bXZ1S3RmNDNqNklHNDM3aUlxRjBlMjV0aXY5ZTVpd3g1RmIiLCJtYWMiOiJkNjMxNWM0MDM0ZGU3ZDZmZDU3ODE5NTAwMzM3ZDFlMDY0NmNlNDExNzUwNTVhOWVkMDgxZmVhZjdhMWQ5NjNmIiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 03:12:41 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IlhQbDJiMUNsQy9US3ZyUGhFQmVydlE9PSIsInZhbHVlIjoicUpwdDV0cWJnVWtNdllabSs0Q0JuWEdDQ2lTRWVxaWFON2NWeVhuM3dMZ0d2ZDJlaUczaHNkemUvRms2aHJRNDA2V21pN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjJtSVVOUUFuV0FhcGJtODJlNVV3SHc9PSIsInZhbHVlIjoib2REdmxJaXdwbitMMVZZekxzc1liRFJpNWZmaVp6dHJLQ1IvenN4bEVtYTZ1WnJySVlXMDFRc2taVkdEaTRuZXNraE5VRTQ2dmN5QjBOZkF1ckRMSTB0NWJiV0g2dndQbUM3b09wWUVianhOWnZVc2FTQmVCRXlNTHdPUW9lTmYiLCJtYWMiOiIwNWI2MzY4YmMyNWU5ZTJjNDVkNDFjYzhmMzJjZTEwNGFjNGMzNGE1OThmZDA2ZjFkNTE5MmJiN2NiNjJjOWZkIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjJtSVVOUUFuV0FhcGJtODJlNVV3SHc9PSIsInZhbHVlIjoib2REdmxJaXdwbitMMVZZekxzc1liRFJpNWZmaVp6dHJLQ1IvenN4bEVtYTZ1WnJySVlXMDFRc2t" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "8W2FvSL0vB5ihLXhqoP1vVcKKKcIbJYPMf8rEuh7" "uc_cart_id" => "2149c089bdf0979913295a11bf94d87c" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/10419" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 15:12:41GET/chapter/104191121911