Venoms and Isolated Toxins from Snakes of Medical Impact in the Northeast Argentina: State of the Art. Potential Pharmacological Applications

María    Emilia   Garcia Denegri; Soledad      Bustillo; Claudia    Carolina   Gay; Andrea      Van De Velde; Gabriela      Gomez; Silvina      Echeverría; María    Del Carmen   Gauna Pereira; Silvana      Maruñak; Sandra      Nuñez; Fabián      Bogado; Matías      Sanchez; Gladys    Pamela   Teibler; Luciano      Fusco; Laura    Cristina Ana   Leiva
doi:10.2174/1568026619666190725094851
Abstract

Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore, constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.
Keywords: Bothrops alternatus, Bothrops diporus, Crotalus durisus terrificus, Phospholipases A2, Serinoproteases, Metalloproteinases, Serine/thrombin-like proteinases, Crotoxin, Snake venom.
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DOI https://dx.doi.org/10.2174/1568026619666190725094851	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294
Current Topics in Medicinal Chemistry

Venoms and Isolated Toxins from Snakes of Medical Impact in the Northeast Argentina: State of the Art. Potential Pharmacological Applications

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