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General Review Article

当前纳米医学中的自组装肽：用于药物输送的多功能纳米材料。

卷 27, 期 29, 2020

页: [4855 - 4881] 页: 27

弟呕挨: 10.2174/0929867326666190712154021

价格: $65

摘要

背景：现代纳米医学的发展很大程度上取决于新型材料作为药物输送系统的参与。 为了最大化药物的治疗效果并最小化其副作用，已经广泛研究了许多天然或合成材料用于药物递送。 在这些材料中，仿生自组装肽（SAP）近年来受到越来越多的关注。 考虑到为药物输送而设计的SAP数量迅速增长，对基于SAP的药物输送系统的设计方式进行总结将是有益的。 方法：我们概述了已作为不同药物的载体进行研究的不同SAP的研究工作，重点是SAP纳米材料的设计以及它们在不同策略中如何用于药物递送。 结果：根据化学互补性和结构相容性的基本规律，可以设计离子自互补肽，肽两亲性和表面活性剂样肽等SAP。 根据肽材料和所递送药物的特性，可以采用不同的策略（例如水凝胶包埋，疏水相互作用，静电相互作用，共价结合或它们的组合）来制备SAPs-药物复合物，从而实现缓慢释放， 有针对性或对环境敏感的药物交付。 此外，某些SAP也可以与其他类型的材料组合以进行药物输送，甚至可以自己充当药物。 结论：已经按照各种策略设计了各种类型的SAP，并将其用于药物输送，这表明SAP作为一类通用的纳米材料在纳米医学领域具有广阔的发展潜力。

关键词: 自组装，肽，水凝胶，纳米颗粒，药物载体，控释，靶向递送。

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