Abstract
Aminoglycoside antibiotics remain to the present date as important chemotherapeutic agents, which have been in clinical use for over 50 years. These antibiotics are multifunctional and have been challenging targets for synthetic chemists. Recent developments in understanding of the mechanism of action and of resistance to these agents have stimulated additional interest in these antibiotics. The present report discussed these efforts in the field for the past few years.
Keywords: Aminoglycoside antibiotics, chemotheraputic agent, Kanamycin B, Neomycine, Gentamicin, deoxystreptamine
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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