Sugar Nucleotide-Modifying Enzymes

Title: Sugar Nucleotide-Modifying Enzymes

Volume: 5 Issue: 2

Author(s): Martin E. Tanner

Affiliation:

Keywords: Sugar Nucleotide, Modifying Enzymes, biosynthetic pathway, Decarboxylase, Dehydratases, Branched changed, UDP glucose, MurA reactio

Abstract: Sugar nucleotides serve as the activated forms of carbohydrates that are used in a wide range of biosynthetic pathways. Instead of building up the sugar nucleotide from the free sugar itself, nature often chooses to modify the donor portion of a pre-existing sugar nucleotide in a biosynthetically efficient manner. In doing so a rich variety of catalytic strategies are employed and this review focuses on recent mechanistic and structural studies of the sugar nucleotide-modifying enzymes. The review is organized around the types of reactions catalyzed and contains the following sections Epimerases/Mutases/Decarboxylases, Eliminations and Substitutions, Oxidation and Reduction, and Substitutions on the Periphery of Sugar Nucleotides.

Cite this article as:

Tanner E. Martin, Sugar Nucleotide-Modifying Enzymes, Current Organic Chemistry 2001; 5 (2) . https://dx.doi.org/10.2174/1385272013375643