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Current Bioactive Compounds

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ISSN (Online): 1875-6646

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Review Article

Anti-inflammatory Plant Polyphenolics and Cellular Action Mechanisms

Author(s): Reyaz H. Mir* and Mubashir H. Masoodi*

Volume 16, Issue 6, 2020

Page: [809 - 817] Pages: 9

DOI: 10.2174/1573407215666190419205317

Price: $65

Abstract

Background: Polyphenolics, a group of natural substances with a wide distribution in the plant kingdom present a great diversity of biological activities such as anti-oxidative, anti-inflammatory, anti-mutagenic, anti-carcinogenic, modulation of enzyme activity, prevention of CHD, etc. The objective of this review was to describe the relevant aspects of polyphenolics, reporting the different known groups, the probable mechanisms by which they act as anti-inflammatory agents. An attempt was also made to enumerate the possible leads e.g. curcumin, resveratrol, baicalein for further development.

Methods: For peer-reviewed research literature we undertook a structured search of bibliographic databases using a focused review question. The quality of retrieved papers was appraised using standard tools. The systemic review consists of research using scientific databases such as PubMed, Scopus, Science Direct, and Google Scholar.

Research: Compounds like Quercetin, luteolin, apigenin, fisetin, wogonin, and baicalein showed antiinflammatory activity in-vitro through different cellular mechanisms and these were also reported to possess significant anti-inflammatory activity in animal models of inflammation.

Conclusion: It is evident that polyphenolic compounds such as flavonoids, lignans, phloroglucinols, stilbenes, diarylheptanoids, quinones, and phenylpropanoids exhibited significant anti-inflammatory activity in-vivo as well as in-vitro. Although, these active compounds are not drugs per se, however, they deserve further investigation as potential candidates for anti-inflammatory drug development through preclinical and clinical studies.

Keywords: Polyphenolics, inflammation, cox-1, cox-2, TNF-α, human epithelial cells.

Graphical Abstract

[1]
Vodovotz, Y.; Constantine, G.; Rubin, J.; Csete, M.; Voit, E.O.; An, G. Mechanistic simulations of inflammation: Current state and future prospects. Math. Biosci., 2009, 217(1), 1-10.
[http://dx.doi.org/10.1016/j.mbs.2008.07.013] [PMID: 18835282]
[2]
Medzhitov, R. Origin and physiological roles of inflammation. Nature, 2008, 454(7203), 428-435.
[http://dx.doi.org/10.1038/nature07201] [PMID: 18650913]
[3]
Lawrence, T.; Fong, C. The resolution of inflammation: anti-inflammatory roles for NF-kappaB. Int. J. Biochem. Cell Biol., 2010, 42(4), 519-523.
[http://dx.doi.org/10.1016/j.biocel.2009.12.016] [PMID: 20026420]
[4]
(a)Woolf, A.D.; Pfleger, B. Burden of major musculoskeletal conditions. Bull. World Health Organ., 2003, 81(9), 646-656.
[PMID: 14710506]
(b)Smith, R.J. Therapies for rheumatoid arthritis: Hope springs eternal. Drug Discov. Today, 2005, 10(23-24), 1598-1606.
[http://dx.doi.org/10.1016/S1359-6446(05)03636-6] [PMID: 16376819]
[5]
Haynes, R.C. Jr Adrenocorticotropic Hormone; Adrenocortical Steroids and their Synthetic Analogs; Inhibitors of the Synthetic and Actions of Adrenocortical Hormones. In: The pharmacological basis of therapeutics; Laurence L., Brunton; Randa, Hilal-Dandan; Björn C, Knollmann, Eds.; McGraw-Hill: Pennsylvania, 1990; p. 1431.
[6]
Jachak, S.M.; Jachak, S.M. Cyclooxygenase inhibitory natural products: Current status. Curr. Med. Chem., 2006, 13(6), 659-678.
[http://dx.doi.org/10.2174/092986706776055698] [PMID: 16529558]
[7]
Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod., 2007, 70(3), 461-477.
[http://dx.doi.org/10.1021/np068054v] [PMID: 17309302]
[8]
Jachak, S.M.; Saklani, A. Challenges and opportunities in drug discovery from plants. Curr. Sci., 2007, 92(9), 1251-1257.
[9]
Vane, J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol., 1971, 231(25), 232-235.
[http://dx.doi.org/10.1038/newbio231232a0] [PMID: 5284360]
[10]
Silva, M.L.C.; Costa, R.S.; dos Santos Santana, A.; Koblitz, M.G.B. Phenolic compounds, carotenoids and antioxidant activity in plant products. Semin. Cienc. Agrar., 2010, 31(3), 669-682.
[http://dx.doi.org/10.5433/1679-0359.2010v31n3p669]
[11]
Randhir, R.; Lin, Y-T.; Shetty, K. Stimulation of phenolics, antioxidant and antimicrobial activities in dark germinated mung bean sprouts in response to peptide and phytochemical elicitors. Process Biochem., 2004, 39(5), 637-646.
[http://dx.doi.org/10.1016/S0032-9592(03)00197-3]
[12]
(a)Bravo, L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr. Rev., 1998, 56(11), 317-333.
[http://dx.doi.org/10.1111/j.1753-4887.1998.tb01670.x] [PMID: 9838798]
(b)Alasalvar, C.; Grigor, J.M.; Zhang, D.; Quantick, P.C.; Shahidi, F. Comparison of volatiles, phenolics, sugars, antioxidant vitamins, and sensory quality of different colored carrot varieties. J. Agric. Food Chem., 2001, 49(3), 1410-1416.
[http://dx.doi.org/10.1021/jf000595h] [PMID: 11312873]
(c)Korkina, L.G.; De Luca, C.; Kostyuk, V.A.; Pastore, S. Plant polyphenols and tumors: From mechanisms to therapies, prevention, and protection against toxicity of anti-cancer treatments. Curr. Med. Chem., 2009, 16(30), 3943-3965.
[http://dx.doi.org/10.2174/092986709789352312] [PMID: 19747130]
[13]
(a)Benavente-García, O.; Castillo, J.; Marin, F.R.; Ortuño, A.; Del Río, J.A. Uses, and properties of citrus flavonoids. J. Agric. Food Chem., 1997, 45(12), 4505-4515.
[http://dx.doi.org/10.1021/jf970373s] [PMID: 18593176]
(b)Manach, C.; Mazur, A.; Scalbert, A. Polyphenols and prevention of cardiovascular diseases. Curr. Opin. Lipidol., 2005, 16(1), 77-84.
[http://dx.doi.org/10.1097/00041433-200502000-00013] [PMID: 15650567]
(c)Middleton, E., Jr; Kandaswami, C.; Theoharides, T.C. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol. Rev., 2000, 52(4), 673-751.
[PMID: 11121513]
(d)Puupponen-Pimiä, R.; Nohynek, L.; Meier, C.; Kähkönen, M.; Heinonen, M.; Hopia, A.; Oksman-Caldentey, K.M. Antimicrobial properties of phenolic compounds from berries. J. Appl. Microbiol., 2001, 90(4), 494-507.
[http://dx.doi.org/10.1046/j.1365-2672.2001.01271.x] [PMID: 11309059]
(e)Samman, S.; Lyons Wall, P.; Cook, N.C. Flavonoids and coronary heart disease: Dietary perspectives. Nutr. Soc. Aust., 1998, 21, 106-114.
[14]
Ghiringhelli, F.; Rebe, C.; Hichami, A.; Delmas, D. Immunomodulation and anti-inflammatory roles of polyphenols as anticancer agents. Anticancer. Agents Med. Chem., 2012, 12(8), 852-873.
[http://dx.doi.org/10.2174/187152012802650048]
[15]
Heim, K.E.; Tagliaferro, A.R.; Bobilya, D.J. Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem., 2002, 13(10), 572-584.
[http://dx.doi.org/10.1016/S0955-2863(02)00208-5] [PMID: 12550068]
[16]
(a)Kumar, V.; Beniwal, V. Phenols and polyphenols: Promise and peril to human health. Mini Rev. Med. Chem., 2018, 18(15), 1242-1243.
[http://dx.doi.org/10.2174/138955751815180808124616] [PMID: 30152278]
(b)Baur, J.A.; Pearson, K.J.; Price, N.L.; Jamieson, H.A.; Lerin, C.; Kalra, A.; Prabhu, V.V.; Allard, J.S.; Lopez-Lluch, G.; Lewis, K.; Pistell, P.J.; Poosala, S.; Becker, K.G.; Boss, O.; Gwinn, D.; Wang, M.; Ramaswamy, S.; Fishbein, K.W.; Spencer, R.G.; Lakatta, E.G.; Le Couteur, D.; Shaw, R.J.; Navas, P.; Puigserver, P.; Ingram, D.K.; de Cabo, R.; Sinclair, D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 2006, 444(7117), 337-342.
[http://dx.doi.org/10.1038/nature05354] [PMID: 17086191]
(c)Sugimoto, K.; Hanai, H.; Tozawa, K.; Aoshi, T.; Uchijima, M.; Nagata, T.; Koide, Y. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology, 2002, 123(6), 1912-1922.
[http://dx.doi.org/10.1053/gast.2002.37050] [PMID: 12454848]
(d)Elmali, N.; Baysal, O.; Harma, A.; Esenkaya, I.; Mizrak, B. Effects of resveratrol in inflammatory arthritis. Inflammation, 2007, 30(1-2), 1-6.
[http://dx.doi.org/10.1007/s10753-006-9012-0] [PMID: 17115116]
[17]
Baxter, H.; Harborne, J.B.; Moss, G.P. Phytochemical dictionary: a handbook of bioactive compounds from plants; CRC press, 1998.
[http://dx.doi.org/10.4324/9780203483756]
[18]
Rathee, P.; Chaudhary, H.; Rathee, S.; Rathee, D.; Kumar, V.; Kohli, K. Mechanism of action of flavonoids as anti-inflammatory agents: A review. Inflammation & allergy drug targets, 2009, 8(3), 229-235.
[http://dx.doi.org/10.2174/187152809788681029]
[19]
Calixto, J.B.; Otuki, M.F.; Santos, A.R. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor κ B (NF-kappaB). Planta Med., 2003, 69(11), 973-983.
[http://dx.doi.org/10.1055/s-2003-45141] [PMID: 14735432]
[20]
Paul, A.T.; Gohil, V.M.; Bhutani, K.K. Modulating TNF-α signaling with natural products. Drug Discov. Today, 2006, 11(15-16), 725-732.
[http://dx.doi.org/10.1016/j.drudis.2006.06.002] [PMID: 16846800]
[21]
Ende, C.; Gebhardt, R. Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids. Planta Med., 2004, 70(10), 1006-1008.
[http://dx.doi.org/10.1055/s-2004-832630] [PMID: 15490332]
[22]
Ziyan, L.; Yongmei, Z.; Nan, Z.; Ning, T.; Baolin, L. Evaluation of the anti-inflammatory activity of luteolin in experimental animal models. Planta Med., 2007, 73(3), 221-226.
[http://dx.doi.org/10.1055/s-2007-967122] [PMID: 17354164]
[23]
Chen, Y-C.; Shen, S-C.; Chen, L-G.; Lee, T.J.; Yang, L-L. Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem. Pharmacol., 2001, 61(11), 1417-1427.
[http://dx.doi.org/10.1016/S0006-2952(01)00594-9] [PMID: 11331078]
[24]
Laupattarakasem, P.; Houghton, P.J.; Hoult, J.R.S. Anti-inflammatory isoflavonoids from the stems of Derris scandens. Planta Med., 2004, 70(6), 496-501.
[http://dx.doi.org/10.1055/s-2004-827147] [PMID: 15229800]
[25]
Min, B.; Oh, S.R.; Lee, H-K.; Takatsu, K.; Chang, I-M.; Min, K.R.; Kim, Y. Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica. Planta Med., 1999, 65(5), 408-412.
[http://dx.doi.org/10.1055/s-1999-14016] [PMID: 10418325]
[26]
(a)Tuchinda, P.; Reutrakul, V.; Claeson, P.; Pongprayoon, U.; Sematong, T.; Santisuk, T.; Taylor, W.C. Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata. Phytochemistry, 2002, 59(2), 169-173.
[http://dx.doi.org/10.1016/S0031-9422(01)00451-4] [PMID: 11809452]
(b)Yun, J-M.; Kwon, H.; Hwang, J-K. In vitro anti-inflammatory activity of panduratin A isolated from Kaempferia pandurata in RAW264.7 cells. Planta Med., 2003, 69(12), 1102-1108.
[http://dx.doi.org/10.1055/s-2003-45190] [PMID: 14750025]
[27]
Chung, M-I.; Weng, J-R.; Wang, J-P.; Teng, C-M.; Lin, C-N. Antiplatelet and anti-inflammatory constituents and new oxygenated xanthones from Hypericum geminiflorum. Planta Med., 2002, 68(1), 25-29.
[http://dx.doi.org/10.1055/s-2002-19871] [PMID: 11842322]
[28]
(a)Lee, J-H.; Zhou, H.Y.; Cho, S.Y.; Kim, Y.S.; Lee, Y.S.; Jeong, C.S. Anti-inflammatory mechanisms of apigenin: Inhibition of cyclooxygenase- 2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules. Arch. Pharm. Res., 2007, 30(10), 1318-1327.
[http://dx.doi.org/10.1007/BF02980273] [PMID: 18038911]
(b)Nicholas, C.; Batra, S.; Vargo, M.A.; Voss, O.H.; Gavrilin, M.A.; Wewers, M.D.; Guttridge, D.C.; Grotewold, E.; Doseff, A.I. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J. Immunol., 2007, 179(10), 7121-7127.
[http://dx.doi.org/10.4049/jimmunol.179.10.7121] [PMID: 17982104]
[29]
Kim, H.P.; Son, K.H.; Chang, H.W.; Kang, S.S. Anti-inflammatory plant flavonoids and cellular action mechanisms. J. Pharmacol. Sci., 2004, 96(3), 229-245.
[http://dx.doi.org/10.1254/jphs.CRJ04003X] [PMID: 15539763]
[30]
Lee, E-R.; Kang, G-H.; Cho, S-G. Effect of flavonoids on human health: Old subjects but new challenges. Recent Pat. Biotechnol., 2007, 1(2), 139-150.
[http://dx.doi.org/10.2174/187220807780809445] [PMID: 19075837]
[31]
Matsuda, H.; Morikawa, T.; Ando, S.; Toguchida, I.; Yoshikawa, M. Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. Bioorg. Med. Chem., 2003, 11(9), 1995-2000.
[http://dx.doi.org/10.1016/S0968-0896(03)00067-1] [PMID: 12670650]
[32]
Mastuda, H.; Morikawa, T.; Ueda, K.; Managi, H.; Yoshikawa, M. Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-α and IL-4 production from RBL-2H3 cells. Bioorg. Med. Chem., 2002, 10(10), 3123-3128.
[http://dx.doi.org/10.1016/S0968-0896(02)00227-4] [PMID: 12150856]
[33]
Takano-Ishikawa, Y.; Goto, M.; Yamaki, K. Structure-activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: Comparison between subclasses of flavonoids. Phytomedicine, 2006, 13(5), 310-317.
[http://dx.doi.org/10.1016/j.phymed.2005.01.016] [PMID: 16635738]
[34]
Sadik, C.D.; Sies, H.; Schewe, T. Inhibition of 15-lipoxygenases by flavonoids: Structure-activity relations and mode of action. Biochem. Pharmacol., 2003, 65(5), 773-781.
[http://dx.doi.org/10.1016/S0006-2952(02)01621-0] [PMID: 12628491]
[35]
Kim, H.K.; Cheon, B.S.; Kim, Y.H.; Kim, S.Y.; Kim, H.P. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem. Pharmacol., 1999, 58(5), 759-765.
[http://dx.doi.org/10.1016/S0006-2952(99)00160-4] [PMID: 10449184]
[36]
Deschamps, J.D.; Kenyon, V.A.; Holman, T.R. Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. Bioorg. Med. Chem., 2006, 14(12), 4295-4301.
[http://dx.doi.org/10.1016/j.bmc.2006.01.057] [PMID: 16500106]
[37]
Wube, A.A.; Bucar, F.; Asres, K.; Gibbons, S.; Adams, M.; Streit, B.; Bodensieck, A.; Bauer, R. Knipholone, a selective inhibitor of leukotriene metabolism. Phytomedicine, 2006, 13(6), 452-456.
[http://dx.doi.org/10.1016/j.phymed.2005.01.012] [PMID: 16716917]
[38]
Marsik, P.; Kokoska, L.; Landa, P.; Nepovim, A.; Soudek, P.; Vanek, T. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med., 2005, 71(8), 739-742.
[http://dx.doi.org/10.1055/s-2005-871288] [PMID: 16142638]
[39]
(a)Aggarwal, B.B.; Shishodia, S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol., 2006, 71(10), 1397-1421.
[http://dx.doi.org/10.1016/j.bcp.2006.02.009] [PMID: 16563357]
(b)Folmer, F.; Jaspars, M.; Dicato, M.; Diederich, M. Marine natural products as targeted modulators of the transcription factor NF-kappaB. Biochem. Pharmacol., 2008, 75(3), 603-617.
[http://dx.doi.org/10.1016/j.bcp.2007.07.044] [PMID: 17919455]
[40]
Kang, B.Y.; Chung, S.W.; Kim, T.S. Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by parthenolide, a predominant sesquiterpene lactone in Tanacetum parthenium: Involvement of nuclear factor-kappaB. Immunol. Lett., 2001, 77(3), 159-163.
[http://dx.doi.org/10.1016/S0165-2478(01)00211-5] [PMID: 11410248]
[41]
Abourashed, E.A.; Muhammad, I.; Resch, M.; Bauer, R.; el-Feraly, F.S.; Hufford, C.D. Inhibitory effects of maesanin and analogs on arachidonic acid metabolizing enzymes. Planta Med., 2001, 67(4), 360-361.
[http://dx.doi.org/10.1055/s-2001-14316] [PMID: 11458456]
[42]
(a)Xiang, M-X.; Xu, Z.; Su, H-W.; Hu, J.; Yan, Y-J. Emodin-8-O-β- D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells. Molecules, 2011, 16(1), 728-737.
[http://dx.doi.org/10.3390/molecules16010728] [PMID: 21245807]
(b)Recio, M.C.; Andujar, I.; Rios, J.L. Anti-inflammatory agents from plants: Progress and potential. Curr. Med. Chem., 2012, 19(14), 2088-2103.
[http://dx.doi.org/10.2174/092986712800229069] [PMID: 22414101]
[43]
Huang, Q.; Shen, H-M.; Ong, C-N. Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem. Pharmacol., 2004, 68(2), 361-371.
[http://dx.doi.org/10.1016/j.bcp.2004.03.032] [PMID: 15194008]
[44]
Weng, J-R.; Tsao, L-T.; Wang, J-P.; Wu, R-R.; Lin, C-N. Anti-inflammatory phloroglucinols and terpenoids from Garcinia subelliptica. J. Nat. Prod., 2004, 67(11), 1796-1799.
[http://dx.doi.org/10.1021/np049811x] [PMID: 15568764]
[45]
Appendino, G.; Ottino, M.; Marquez, N.; Bianchi, F.; Giana, A.; Ballero, M.; Sterner, O.; Fiebich, B.L.; Munoz, E. Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol α-Pyrone from Helichrysum italicum ssp. microphyllum. J. Nat. Prod., 2007, 70(4), 608-612.
[http://dx.doi.org/10.1021/np060581r] [PMID: 17315926]
[46]
Zschocke, S.; van Staden, J.; Paulus, K.; Bauer, R.; Horn, M.M.; Munro, O.Q.; Brown, N.J.; Drewes, S.E. Stereostructure and anti-inflammatory activity of three diastereomers of ocobullenone from Ocotea bullata. Phytochemistry, 2000, 54(6), 591-595.
[http://dx.doi.org/10.1016/S0031-9422(00)00163-1] [PMID: 10963452]
[47]
Hwang, B.Y.; Lee, J-H.; Nam, J.B.; Hong, Y-S.; Lee, J.J. Lignans from Saururus chinensis inhibiting the transcription factor NF-kappaB. Phytochemistry, 2003, 64(3), 765-771.
[http://dx.doi.org/10.1016/S0031-9422(03)00391-1] [PMID: 13679100]
[48]
Saleem, M.; Kim, H.J.; Ali, M.S.; Lee, Y.S. An update on bioactive plant lignans. Nat. Prod. Rep., 2005, 22(6), 696-716.
[http://dx.doi.org/10.1039/b514045p] [PMID: 16311631]
[49]
Cho, J.Y.; Baik, K.U.; Yoo, E.S.; Yoshikawa, K.; Park, M.H. In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica. J. Nat. Prod., 2000, 63(9), 1205-1209.
[http://dx.doi.org/10.1021/np9902791] [PMID: 11000020]
[50]
Prieto, J.M.; Giner, R.M.; Recio Mf, M.C.; Schinella, G.; Máñez, S.; Ríos, J.L. Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum. Planta Med., 2002, 68(4), 359-360.
[http://dx.doi.org/10.1055/s-2002-26747] [PMID: 11988863]
[51]
(a)Rahman, I.; Biswas, S.K.; Kirkham, P.A. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem. Pharmacol., 2006, 72(11), 1439-1452.
[http://dx.doi.org/10.1016/j.bcp.2006.07.004] [PMID: 16920072]
(b)Khanna, D.; Sethi, G.; Ahn, K.S.; Pandey, M.K.; Kunnumakkara, A.B.; Sung, B.; Aggarwal, A.; Aggarwal, B.B. Natural products as a gold mine for arthritis treatment. Curr. Opin. Pharmacol., 2007, 7(3), 344-351.
[http://dx.doi.org/10.1016/j.coph.2007.03.002] [PMID: 17475558]
(c)Baur, J.A.; Sinclair, D.A. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov., 2006, 5(6), 493-506.
[http://dx.doi.org/10.1038/nrd2060] [PMID: 16732220]
[52]
Selvam, C.; Jachak, S.M.; Oli, R.G.; Thilagavathi, R.; Chakraborti, A.K.; Bhutani, K. A new cyclooxygenase (COX) inhibitory pterocarpan from Indigofera aspalathoides: structure elucidation and determination of binding orientations in the active sites of the enzyme by molecular docking. Tetrahedron Lett., 2004, 45(22), 4311-4314.
[http://dx.doi.org/10.1016/j.tetlet.2004.04.010]
[53]
(a)Csaki, C.; Keshishzadeh, N.; Fischer, K.; Shakibaei, M. Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem. Pharmacol., 2008, 75(3), 677-687.
[http://dx.doi.org/10.1016/j.bcp.2007.09.014] [PMID: 17959154]
(b)Kundu, J.K.; Shin, Y.K.; Surh, Y-J. Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets. Biochem. Pharmacol., 2006, 72(11), 1506-1515.
[http://dx.doi.org/10.1016/j.bcp.2006.08.005] [PMID: 16999939]
[54]
Elmali, N.; Esenkaya, I.; Harma, A.; Ertem, K.; Turkoz, Y.; Mizrak, B. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm. Res., 2005, 54(4), 158-162.
[http://dx.doi.org/10.1007/s00011-004-1341-6] [PMID: 15883738]
[55]
Chung, K.O.; Kim, B.Y.; Lee, M.H.; Kim, Y.R.; Chung, H.Y.; Park, J.H.; Moon, J.O. In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. J. Pharm. Pharmacol., 2003, 55(12), 1695-1700.
[http://dx.doi.org/10.1211/0022357022313] [PMID: 14738598]
[56]
(a)Chung, E.Y.; Kim, B.H.; Lee, M.K.; Yun, Y-P.; Lee, S.H.; Min, K.R.; Kim, Y. Anti-inflammatory effect of the oligomeric stilbene α-Viniferin and its mode of the action through inhibition of cyclooxygenase-2 and inducible nitric oxide synthase. Planta Med., 2003, 69(8), 710-714.
[http://dx.doi.org/10.1055/s-2003-42787] [PMID: 14531020]
(b)Lee, J.Y.; Kim, J-H.; Kang, S.S.; Bae, C.S.; Choi, S.H. The effects of α-viniferin on adjuvant-induced arthritis in rats. Am. J. Chin. Med., 2004, 32(4), 521-530.
[http://dx.doi.org/10.1142/S0192415X04002168] [PMID: 15481642]
[57]
Cui, X.; Jin, Y.; Hofseth, A.B.; Pena, E.; Habiger, J.; Chumanevich, A.; Poudyal, D.; Nagarkatti, M.; Nagarkatti, P.S.; Singh, U.P.; Hofseth, L.J. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prev. Res. (Phila.), 2010, 3(4), 549-559.
[http://dx.doi.org/10.1158/1940-6207.CAPR-09-0117] [PMID: 20332304]
[58]
(a)Goel, A.; Kunnumakkara, A.B.; Aggarwal, B.B. Curcumin as “Curecumin”: From kitchen to clinic. Biochem. Pharmacol., 2008, 75(4), 787-809.
[http://dx.doi.org/10.1016/j.bcp.2007.08.016] [PMID: 17900536]
(b)Singh, S. From exotic spice to modern drug? Cell, 2007, 130(5), 765-768.
[http://dx.doi.org/10.1016/j.cell.2007.08.024] [PMID: 17803897]
(c)Chattopadhyay, I.; Biswas, K.; Bandyopadhyay, U.; Banerjee, R.K. Turmeric and curcumin: Biological actions and medicinal applications. Curr. Sci., 2004, 87, 44-53.
(d)Maheshwari, R.K.; Singh, A.K.; Gaddipati, J.; Srimal, R.C. Multiple biological activities of curcumin: a short review. Life Sci., 2006, 78(18), 2081-2087.
[http://dx.doi.org/10.1016/j.lfs.2005.12.007] [PMID: 16413584]
[59]
(a)Natarajan, C.; Bright, J.J. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase- STAT pathway in T lymphocytes. J. Immunol., 2002, 168(12), 6506-6513.
[http://dx.doi.org/10.4049/jimmunol.168.12.6506] [PMID: 12055272]
(b)Liacini, A.; Sylvester, J.; Li, W.Q.; Huang, W.; Dehnade, F.; Ahmad, M.; Zafarullah, M. Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Exp. Cell Res., 2003, 288(1), 208-217.
[http://dx.doi.org/10.1016/S0014-4827(03)00180-0] [PMID: 12878172]
[60]
Banerjee, M.; Tripathi, L.M.; Srivastava, V.M.; Puri, A.; Shukla, R. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacol. Immunotoxicol., 2003, 25(2), 213-224.
[http://dx.doi.org/10.1081/IPH-120020471] [PMID: 12784914]
[61]
(a)Bi, X.L.; Yang, J.Y.; Dong, Y.X.; Wang, J.M.; Cui, Y.H.; Ikeshima, T.; Zhao, Y.Q.; Wu, C.F. Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia. Int. Immunopharmacol., 2005, 5(1), 185-193.
[http://dx.doi.org/10.1016/j.intimp.2004.08.008] [PMID: 15589480]
(b)Wu, C-C.; Wu, C-I.; Wang, W-Y.; Wu, Y-C. Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins. Planta Med., 2007, 73(5), 439-443.
[http://dx.doi.org/10.1055/s-2007-967173] [PMID: 17566146]
[62]
Patel, B.; Patel, S.; Hoffman, R. Inhibition of cyclo-oxygenase-2 expression in mouse macrophages by 4-(3-methyl-but-1-enyl)-3,5,3′,4′-tetrahydroxystilbene, a resveratrol derivative from peanuts. Phytother. Res., 2005, 19(6), 552-555.
[http://dx.doi.org/10.1002/ptr.1698] [PMID: 16114095]
[63]
Lee, J.Y.; Woo, E-R.; Kang, K.W. Inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by acteoside through blocking of AP-1 activation. J. Ethnopharmacol., 2005, 97(3), 561-566.
[http://dx.doi.org/10.1016/j.jep.2005.01.005] [PMID: 15740896]
[64]
Matsui, T.; Ito, C.; Itoigawa, M.; Okada, T.; Furukawa, H. Anti-inflammatory activity of phenylpropanoids and phytoquinoids from Illicium species in RBL-2H3 cells. Planta Med., 2007, 73(7), 662-665.
[http://dx.doi.org/10.1055/s-2007-981528] [PMID: 17538871]
[65]
Korkina, L.; Kostyuk, V.; De Luca, C.; Pastore, S. Plant phenylpropanoids as emerging anti-inflammatory agents. Mini Rev. Med. Chem., 2011, 11(10), 823-835.
[http://dx.doi.org/10.2174/138955711796575489] [PMID: 21762105]

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