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Review Article

基于聚合物的微球控制蛋白质和肽递送系统的最新进展

卷 26, 期 13, 2019

页: [2285 - 2296] 页: 12

弟呕挨: 10.2174/0929867326666190409130207

价格: $65

摘要

由可生物降解的聚合物制成的用于蛋白质和肽药物递送的持续释放系统已经受到全世界的学术研究人员和主要制药公司的广泛关注。已经应用各种类型的可生物降解材料，包括天然和合成聚合物，以形成蛋白质和肽药物载体。在这些候选材料中，聚乳酸（PLA）和聚乳酸 - 共 - 羟基乙酸（PLGA）是蛋白质和肽微球体开发中最常用的可生物降解材料。此外，已经开发了许多微球制备技术，包括喷雾干燥，凝聚，多乳液溶剂蒸发方法和微孔膜乳化，用于制备微球。在本综述中，我们特别总结并简要介绍了用于制造微球作为蛋白质递送系统的材料和方法。还讨论了成功输送蛋白质的现有机会和挑战。

关键词: 缓释系统，蛋白质和多肽药物，微球，药物输送，微孔膜乳化技术，可生物降解材料，组织工程。

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