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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Detoxification of Heterocyclic Aromatic Amines by Probiotic to Inhibit Medical Hazards

Author(s): Kianoush Khosravi-Darani*, F. Barzegar and M. Baghdadi

Volume 19, Issue 15, 2019

Page: [1196 - 1203] Pages: 8

DOI: 10.2174/1389557519666190318102201

Price: $65

Abstract

Cancer is the second leading factor of human death in the world. Long-term consumption of cooked red meat brings about various types of cancers like colorectal cancer due to the formation of Heterocyclic Aromatic Amines (HAAs) during the heating process of meat. There are various solutions for the reduction of these toxicants. The aim of this article is to describe probiotic as one of the possible strategies for bioremoval of these carcinogenic and mutagenic substances and change food to functional one as well. The mechanism of biodetoxification is binding by probiotics, which depends on some variables including the probiotic characteristics, kind and content of the mutagens, as well as some properties of media. In this article, after introducing detoxification ability of probiotics and listing of all reported probiotics in this field, the influencing variables are surveyed and finally, opportunities and problems of HAA bioremoval by probiotics are described.

Keywords: Bioremoval, cancerogenic food, decontamnation, heterocyclic aromatic amines, probiotics, hazards.

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