Generic placeholder image

Current Environmental Engineering

Editor-in-Chief

ISSN (Print): 2212-7178
ISSN (Online): 2212-7186

Research Article

Development of Graphene Oxide-Trihexyphenidyl Hydrochloride Nanohybrid and Release behavior

Author(s): Pradip M. Jawanjal, Pritam B. Patil, Jayesh Patil, Mrunal Waghulde and Jietndra B. Naik*

Volume 6, Issue 2, 2019

Page: [134 - 140] Pages: 7

DOI: 10.2174/2212717806666190313153239

Abstract

Background: The demand of an efficient nanocarrier in drug delivery, graphene and its derivatives are emerging as a rising star due to its remarkable chemical and structural properties.

Objective: Graphene oxide (GO) has high surface area and ability to load high amount of aromatic drugs. Hence, the objective of the research was to load Trihexyphenidyl hydrochloride (THP), antiparkinsonian drug on GO ultrasonically by π-π stacking interaction.

Methods: GO was synthesized by the modified Hummer method. The conjugation of GOTHP was generated by using Design-Expert Software and release study of GO-THP nanohybrids was performed in the dissolution tester by using a dialysis membrane.

Results: By varying an amount of GO and THP, the effect on loading efficiency and drug release was studied. THP showed sustained release behavior with release efficiency of 89% to 98% over 8 h. GO-THP complex was characterized by UV-vis spectrophotometer, FTIR, FESEM and XRD analysis.

Conclusion: GO-THP complex showed better-sustained release of the drug and can be useful for the reduction dose frequency as well as adverse effect with better patient compliance.

Keywords: Graphene oxide, trihexyphenidyl hydrochloride, parkinson's, nanocarrier, nanohybrid, FTIR.

Graphical Abstract

[1]
Sherlock S, Tabakman S, et al. Photothermally enhanced drug delivery by ultra-small multifunctional FeCo/graphitic shell nanocrystals. ACS Nano 2011; 5(2): 1505-12.
[2]
Kim H, Namgung R, Singha K, Oh IK, Kim WJ. Graphene oxide–polyethylenimine nanoconstruct as a gene delivery vector and bioimaging tool. Bioconjug Chem 2011; 22(12): 2558-67.
[3]
Pan Y, Bao H, Sahoo NG, Wu T, Li L. Water‐soluble poly (N‐isopropylac-rylamide)-graphene sheets synthesized via click chemistry for drug delivery. Adv Funct Mater 2011; 21(14): 2754-63.
[4]
Nahain AA, Lee JE, Jeong JH, Park SY. Photoresponsive fluorescent reduced graphene oxide by spiropyran conjugated hyaluronic acid for in vivo imaging and target delivery. Biomacromolecules 2013; 14(11): 4082-90.
[5]
Kulkarni S, Patil P, Mujumdar A, Naik J. Synthesis and evaluation of gas sensing properties of PANI, PANI/SnO2 and PANI/SnO2/-rGO nanocomposites at room temperature. Inorg Chem Commun 2018; 96: 90-6.
[6]
Patil P, Gaikwad G, Patil DR, Naik J. Gas sensitivity study of polypyrrole decorated graphene oxide thick film. J Inst Eng India Ser D 2016; 97(1): 47-53.
[7]
Weaver CL, LaRosa JM, Luo X, Cui XT. Electrically controlled drug delivery from graphene oxide nanocomposite films. ACS Nano 2014; 8(2): 1834-43.
[8]
Wate PS, Banerjee SS, Jalota-Badhwar A, et al. Cellular imaging using biocompatible dendrimer-functionalized graphene oxide-based fluorescent probe anchored with magnetic nanopartcles. Nanotechnology 2012; 23(41): 415101.
[9]
Chen B, Liu M, Zhang L, Huang J, Yao J, Zhang Z. Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector. J Mater Chem 2011; 21: 7736-41.
[10]
Marcano D, Kosynkin DV, Berlin JM, et al. Improved synthesis of graphene oxide. ACS Nano 2010; 4(8): 4806-14.
[11]
Gaikwad G, Patil P, Patil D, Naik J. Synthesis and evaluation of gas sensing properties of PANI based graphene oxide nanocomposites. Mater Sci Eng B 2017; 218: 14-22.
[12]
Zheng T, Li M. Restoring basal planes of graphene oxides for highly efficient loading and delivery of β-lapachone. Mol Pharm 2012; 9(3): 615-21.
[13]
Liu J, Cui L, Losic D. Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater 2013; 9(12): 9243-57.
[14]
Goenka S, Sant V, Sant S. Graphene-based nanomaterials for drug delivery and tissue engineering. J Control Release 2014; 173: 75-88.
[15]
Muthoosamy K, Bai GR, Manickam S. Graphene and graphene oxide as a docking station for modern drug delivery system. Curr Drug Deliv 2014; 11(6): 701-18.
[16]
Wang Y, Wang K, Zhao J, et al. Multifunctional mesoporous silica-coated graphene nanosheet used for chemo-photothermal synergistic targeted therapy of glioma. J Am Chem Soc 2013; 135(12): 4799-804.
[17]
Feng L, Yang X, Shi X, et al. Polyethylene glycol and polyethylenimine dual‐functionalized nano‐graphene oxide for photothermally enhanced gene delivery. Small 2013; 9(11): 1989-97.
[18]
Kim H, Lee D, Kim J, Kim TI, Kim WJ. Photothermally triggered cytosolic drug delivery via endosome disruption using a functionalized reduced graphene oxide. ACS Nano 2013; 7(8): 6735-46.
[19]
Yang X, Zhang X, Liu Z, Ma Y, Huang Y, Chen Y. High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. J Phys Chem C 2008; 112(45): 17554-8.
[20]
Gajjar SK, Sailor GU, Seth AK, Patel PB. A review on targeted drug delivery: Magnetic drug delivery system. J Pharm Sci Bioscientific Res 2011; 1(2): 125-33.
[21]
Deshmukh R, Naik J. Optimization of sustained release aceclofenac microspheres using response surface methodology. Mater Sci Eng C 2015; 48: 197-204.
[22]
Deshmukh R, Naik J. Diclofenac sodium-loaded Eudragit® microspheres: Optimization using statistical experimental design. J Pharm Innov 2013; 8: 276-87.
[23]
Kulkarni SB, Lokhande RS, Jadhav PV, Janwadkar SP, Rana PK, Yadav DK. Simultaneous estimation of risperidone and trihexyphenidyl hydrochloride by using isocratic reverse phase high performance liquid chromatography method. World J Pharm Res 2014; 3(2): 3230-7.
[24]
Brocks D. Anticholinergic drugs used in Parkinson’s disease: An overlooked class of drugs from a pharmacokinetic perspective. J Pharm Pharm Sci 1999; 2(2): 39-46.
[25]
Paulchamy B, Arthi G, Lignesh BD. A simple approach to stepwise synthesis of graphene oxide nanomaterial. J Nanomed Nanotechnol 2015; 6(1): 1-4.
[26]
Shahriary L, Athawale A. Graphene oxide synthesized by using modified hummers approach. Int J Renew Energ Environ Eng 2014; 2(1): 58-63.
[27]
Verma U, Naik JB, Deshmukh R, Mishra S. Development of biodegradable glimepiride loaded chitosan nano particles: A factorial design approach. Curr Environ Eng 2018; 5(1): 68-77.
[28]
Shrimal P, Sanklecha H, Patil P, Mujumdar A, Naik J. Biodiesel production in tubular microreactor: Optimization by response surface methodology. Arab J Sci Eng 2018; 43(11): 6133-41.
[29]
Patil P, Gaikwad G, Patil DR, Naik J. Synthesis of 1-D ZnO nanorods and polypyrrole/1-D ZnO nanocomposites for photocatalysis and gas sensor applications. Bull Mater Sci 2016; 39(3): 655-65.
[30]
Patil P, Khairnar G, Naik J. Preparation and statistical optimization of Losartan Potassium loaded nanoparticles using Box Behnken factorial design: Microreactor precipitation. Chem Eng Res Des 2015; 104: 98-109.

© 2024 Bentham Science Publishers | Privacy Policy