Review Article

用于3D打印固化组织工程植入物的可光聚合树脂

卷 20, 期 8, 2019

页: [823 - 838] 页: 16

弟呕挨: 10.2174/1389450120666190114122815

价格: $65

摘要

随着廉价和高精度3D打印设备的出现,大量的研究活动被释放到新的可再吸收的聚合物材料中,可以使用三种方法进行印刷:用于生物打印和生物印刷的水凝胶,烧结聚合物粉末和固体固化(光交联) )树脂。此外,还有一场比赛要了解细胞外基质成分和细胞信号分子的作用,并采用方法将这些材料纳入可再吸收的植入物中。这些嵌合材料以及用于研究器官或在芯片上创建实验室的微流体装置都受到了极大关注,尽管有限数量的聚合物系统可以适应这些构造所需的生物制造过程。也许最有说服力的是可光交联的可再吸收聚合物和制造添加剂的数量有限(例如,光引发剂,溶剂,染料,分散剂,乳化剂或生物活性分子,如微RNA,肽,蛋白质,外泌体,胶束或陶瓷晶体) )可用于生产经过生物相容性验证的树脂。需要取得进展以操纵3D打印支架的4D特性,例如植入前细胞培养,机械特性,再吸收动力学,药物递送,支架表面功能化,细胞附着,细胞增殖,细胞成熟或组织重塑;所有这些都是再生医学应用所必需的,同时扩大临床使用中的一小部分材料。本手稿回顾了最常见的固化支架和医疗器械可光聚合树脂的基础,即聚乙二醇(PEG),聚(D,L-丙交酯)(PDLLA),聚-ε-己内酯(PCL),和聚(丙烯富马酸酯)(PPF),以及3D打印组织工程植入物的方法学进展(例如,通过立体光刻[SLA],连续数字光处理[cDLP]和液晶显示器[LCD])。

关键词: 增材制造(3D打印),生物相容性,交联剂,共交联剂,细胞毒性,数字光处理(DLP),数字微镜器件(DMD),分散剂,乳化剂,制造添加剂,光衰减器,液晶显示器(LCD),掩模投影 ,光交联,光引发剂,再生医学,立体光刻,组织工程。

图形摘要

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