Cardiovascular Effects of Flavonoids

doi:10.2174/0929867326666181220094721
摘要

心血管疾病（CVD）是全球范围内的主要死亡原因，尤其是在西方社会。黄酮类化合物是一大类广泛分布在植物中的多酚化合物，大量存在于水果和蔬菜中。几项流行病学研究发现，类黄酮摄入与CVD死亡率呈反比关系。类黄酮的抗氧化作用被认为是类黄酮和其他多酚的主要作用机理。近年来，通过类黄酮与多种蛋白质靶标即激酶的直接相互作用调节信号通路的作用已得到越来越多的认识，并参与其心血管保护作用。在体外和动物实验模型中，有强有力的证据表明某些类黄酮可诱导血管扩张作用，改善内皮功能障碍和胰岛素抵抗，发挥血小板抗凝和抗动脉粥样硬化作用，并降低血压。尽管与多个靶标相互作用，类黄酮还是非常安全的。本文回顾了有关心血管效应的最新证据，这些证据支持了类黄酮对CVD的有益作用以及所涉及的潜在分子靶标。
关键词: 类黄酮，内皮功能，高血压，血小板凝集，动脉粥样硬化，胰岛素抵抗，心肌缺血，中风。
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DOI https://dx.doi.org/10.2174/0929867326666181220094721	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

黄酮类化合物的心血管作用

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当代药物化学

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