Abstract
The following review provides up to date information about the recent progress in synthetic approaches and chemical reactivities to α-(arylhydrazono)-β-ketoaldehydes, mainly using N,N-dimethyl-β-ketoenamines as an efficient starting material. These α - (arylhydrazono)-β-ketoaldehydes have assured to be of biological interest and furnish an inlet to a new class of biologically active heterocyclic compounds for biomedical implementations. The data published until the end of 2017 have been covered.
Keywords: 2-arylhydrazonals, N, N-dimethylenamino-ketones, coupling reactions, α-(arylhydrazono)-β-ketoaldehydes, active methylene, nitrogen-nucleophiles.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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