Elucidating Protein-protein Interactions Through Computational Approaches and Designing Small Molecule Inhibitors Against them for Various Diseases

Title:Elucidating Protein-protein Interactions Through Computational Approaches and Designing Small Molecule Inhibitors Against them for Various Diseases

Volume: 18 Issue: 20

Author(s): Sharanya Sarkar, Khushboo Gulati, Manikyaprabhu Kairamkonda, Amit Mishra and Krishna Mohan Poluri*

Affiliation:

• Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee – 247667, Uttarakhand,India

Keywords: Protein-protein interactions, High throughput screening, Molecular signaling, Structure-function relationships, Small molecule inhibitors, Machine learning.

Abstract: Background: To carry out wide range of cellular functionalities, proteins often associate with one or more proteins in a phenomenon known as Protein-Protein Interaction (PPI). Experimental and computational approaches were applied on PPIs in order to determine the interacting partners, and also to understand how an abnormality in such interactions can become the principle cause of a disease.

Objective: This review aims to elucidate the case studies where PPIs involved in various human diseases have been proven or validated with computational techniques, and also to elucidate how small molecule inhibitors of PPIs have been designed computationally to act as effective therapeutic measures against certain diseases.

Results: Computational techniques to predict PPIs are emerging rapidly in the modern day. They not only help in predicting new PPIs, but also generate outputs that substantiate the experimentally determined results. Moreover, computation has aided in the designing of novel inhibitor molecules disrupting the PPIs. Some of them are already being tested in the clinical trials.

Conclusion: This review delineated the classification of computational tools that are essential to investigate PPIs. Furthermore, the review shed light on how indispensable computational tools have become in the field of medicine to analyze the interaction networks and to design novel inhibitors efficiently against dreadful diseases in a shorter time span.

Cite this article as:

Sarkar Sharanya , Gulati Khushboo , Kairamkonda Manikyaprabhu , Mishra Amit and Poluri Mohan Krishna *, Elucidating Protein-protein Interactions Through Computational Approaches and Designing Small Molecule Inhibitors Against them for Various Diseases, Current Topics in Medicinal Chemistry 2018; 18 (20) . https://dx.doi.org/10.2174/1568026618666181025114903