The Influence of Co-Ligands on Improving Tumor Targeting of ^99mTc-HYNIC Conjugated Peptides

Title:The Influence of Co-Ligands on Improving Tumor Targeting of ^99mTc-HYNIC Conjugated Peptides

Volume: 17 Issue: 2

Author(s): Seyedeh Atekeh Torabizadeh and Seyed Jalal Hosseinimehr

Affiliation:

Keywords: ^99mTc, co-ligand, HYNIC, peptide, radiolabeling, tumor targeting.

Abstract: Technetium-99m (^99mTc) is widely used as a radionuclide for labeling of biomolecules in nuclear medicine practice. 6-hydrazinopyridine-3-carboxylic acid namely HYNIC is one of the best bifunctional chelating agents for attachment of ^99mTc to the biomolecules such as peptides and proteins. Since HYNIC can only occupy one or two coordination sites of ^99mTc, co-ligands are needed to complete the coordination sphere of the technetium. Selection of co-ligands can be impressive on the stability, lipophilicity and biodistribution of ^99mTc-HYNIC conjugated peptides. The aim of this review was to explain the chemical and biological effects of various co-ligands on characteristics of ^99mTc-HYNIC conjugates for tumor or diseases imaging.

Cite this article as:

Torabizadeh Atekeh Seyedeh and Hosseinimehr Jalal Seyed, The Influence of Co-Ligands on Improving Tumor Targeting of ^99mTc-HYNIC Conjugated Peptides, Mini-Reviews in Medicinal Chemistry 2017; 17 (2) . https://dx.doi.org/10.2174/1389557516666160808122335