Abstract
BioActive Compounds (BACs) recovered from food or food by-product matrices are useful in maintaining well being, enhancing human health, and modulating immune function to prevent or to treat chronic diseases. They are also generally seen by final consumers as safe, non-toxic and environment-friendly. Despite the complex process of production, chemical characterization, and assessment of health effects, BACs must also be manufactured in stable and bioactive ingredients to be used in pharmaceutical, food and nutraceutical industry. Generally, vegetable derivatives occur as sticky raw materials with pervasive smell and displeasing flavor. Also, they show critical water solubility and dramatic stability behavior over time, involving practical difficulties for industrial use. Therefore, the development of novel functional health products from natural sources requires the design of a suitable formulation to delivery BACs at the site of action, preserve stability during processing and storage, slow down the degradation processes, mask lousy tasting or smell, and increase the bioavailability, while maintaining the BACs functionality. The present review focuses on human health benefits, BACs composition, and innovative technologies or formulation approaches of natural ingredients from some selected foods and by-products from industrial food transformations.
Keywords: Health products, soy, annurca peels, Citrus bergamia juice, C. aurantium peel, hazelnut by-products.
[http://dx.doi.org/10.1002/1097-0010(20000915)80:12<1744:AID-JSFA725>3.0.CO;2-W]
[http://dx.doi.org/10.1016/j.cofs.2016.02.002]
[http://dx.doi.org/10.1016/S0271-5317(98)00169-9]
[http://dx.doi.org/10.1021/jf020121d] [PMID: 12358447]
[http://dx.doi.org/10.1016/j.ejphar.2008.03.008] [PMID: 18417116]
[http://dx.doi.org/10.1081/FRI-200040606]
[http://dx.doi.org/10.1016/j.jff.2015.06.018]
[http://dx.doi.org/10.3390/nu2121231] [PMID: 22254006]
[http://dx.doi.org/10.2174/157015909787602823] [PMID: 19721819]
[http://dx.doi.org/10.1093/ajcn/78.3.517S] [PMID: 12936943]
[http://dx.doi.org/10.1155/2017/7467962] [PMID: 29204249]
[http://dx.doi.org/10.1080/01635580802143836] [PMID: 18584477]
[http://dx.doi.org/10.1021/jf8006568] [PMID: 18593176]
[http://dx.doi.org/10.3390/nu10010040] [PMID: 29300347]
[http://dx.doi.org/10.1007/s00394-016-1333-7] [PMID: 27757595]
[http://dx.doi.org/10.1080/10408398.2014.989958] [PMID: 26565435]
[http://dx.doi.org/10.1016/j.clnu.2017.12.006] [PMID: 29277346]
[http://dx.doi.org/10.1007/s11101-015-9398-0]
[http://dx.doi.org/10.1001/jamainternmed.2014.8347] [PMID: 25730101]
[http://dx.doi.org/10.1016/j.phrs.2017.12.003] [PMID: 29208493]
[http://dx.doi.org/10.1016/j.jnutbio.2017.07.013] [PMID: 28886437]
[http://dx.doi.org/10.1002/mnfr.201700373] [PMID: 28755406]
[http://dx.doi.org/10.1039/C5FO01541C] [PMID: 27182608]
[http://dx.doi.org/10.1039/C7FO01139C] [PMID: 29068453]
[http://dx.doi.org/10.4172/2252-5211.1000248]
[http://dx.doi.org/10.1186/s40643-017-0148-6]
[http://dx.doi.org/10.1016/j.tifs.2014.08.004]
[http://dx.doi.org/10.1021/jf201801q] [PMID: 21761864]
[http://dx.doi.org/10.1016/j.fitote.2017.10.006] [PMID: 29050970]
[http://dx.doi.org/10.1016/j.seppur.2010.07.007]
[http://dx.doi.org/10.1016/j.seppur.2012.02.036]
[http://dx.doi.org/10.1016/j.trac.2017.07.007]
[http://dx.doi.org/10.1016/j.canlet.2013.02.032] [PMID: 23435377]
[http://dx.doi.org/10.1016/j.jep.2005.11.029] [PMID: 16427228]
[http://dx.doi.org/10.1021/jf404439b] [PMID: 24295170]
[http://dx.doi.org/10.1016/j.copbio.2008.03.003] [PMID: 18406129]
[http://dx.doi.org/10.1039/C4FO01175A] [PMID: 25710906]
[http://dx.doi.org/10.1093/ajcn/81.1.230S] [PMID: 15640486]
[http://dx.doi.org/10.1016/j.lwt.2018.03.048]
[http://dx.doi.org/10.1111/ijfs.13422]
[http://dx.doi.org/10.1080/14786419.2018.1462178] [PMID: 29656659]
[http://dx.doi.org/10.1515/ijfe-2017-0047]
[http://dx.doi.org/10.1007/s11947-017-1880-9]
[http://dx.doi.org/10.1080/02652048.2017.1354939] [PMID: 28715926]
[http://dx.doi.org/10.1007/s13197-017-2790-6] [PMID: 29051636]
[http://dx.doi.org/10.1016/j.jfoodeng.2010.10.015]
[http://dx.doi.org/10.1016/S1773-2247(05)50066-2]
[http://dx.doi.org/10.1016/S1773-2247(07)50018-3]
[http://dx.doi.org/10.1016/j.powtec.2015.04.074]
[http://dx.doi.org/10.1016/j.foodres.2018.02.026] [PMID: 29580481]
[http://dx.doi.org/10.1080/10408398.2012.672939] [PMID: 24915356]
[http://dx.doi.org/10.3892/br.2013.129]
[http://dx.doi.org/10.1111/j.1750-3841.2012.02676.x] [PMID: 22510061]
[http://dx.doi.org/10.1080/10942912.2015.1136936]
[http://dx.doi.org/10.1021/jf034690c] [PMID: 14664529]
[http://dx.doi.org/10.1891/1058-1243.12.3.42] [PMID: 17273351]
[http://dx.doi.org/10.1021/jf0009246] [PMID: 11312815]
[http://dx.doi.org/10.3390/healthcare5020025] [PMID: 28531128]
[http://dx.doi.org/10.1177/2156587213488788]
[http://dx.doi.org/10.4172/2157-7013.1000194]
[http://dx.doi.org/10.3945/jn.109.118315] [PMID: 20484551]
[http://dx.doi.org/10.4162/nrp.2014.8.6.618] [PMID: 25489400]
[http://dx.doi.org/10.1080/10942912.2012.714828]
[http://dx.doi.org/10.3390/medicines4020018] [PMID: 28930233]
[http://dx.doi.org/10.7314/APJCP.2014.15.17.7001] [PMID: 25227781]
[http://dx.doi.org/10.3390/nu8120754] [PMID: 27886135]
[http://dx.doi.org/10.21037/amj.2017.01.01]
[http://dx.doi.org/10.3945/ajcn.116.137281] [PMID: 27927636]
[http://dx.doi.org/10.1038/ejcn.2017.76] [PMID: 28488690]
[http://dx.doi.org/10.1039/C7FO01094J] [PMID: 29043346]
[http://dx.doi.org/10.3390/molecules21010013] [PMID: 26703550]
[http://dx.doi.org/10.4103/0366-6999.174488] [PMID: 26831238]
[http://dx.doi.org/10.1007/s12026-012-8331-5] [PMID: 22484990]
[http://dx.doi.org/10.1111/j.1365-2605.2009.01011.x] [PMID: 19919579]
[http://dx.doi.org/10.1530/REP-11-0369] [PMID: 22223686]
[http://dx.doi.org/10.1177/0884533612456043] [PMID: 22878362]
[http://dx.doi.org/10.1016/j.fshw.2013.08.002]
[http://dx.doi.org/10.1002/ijc.29437] [PMID: 25639758]
[http://dx.doi.org/10.1111/bju.12435] [PMID: 24053483]
[http://dx.doi.org/10.4172/2155-9600.1000470]
[http://dx.doi.org/10.1017/S1368980013003443] [PMID: 24674768]
[http://dx.doi.org/10.1038/srep25939] [PMID: 27170217]
[http://dx.doi.org/10.1016/j.jand.2016.09.036] [PMID: 27914914]
[http://dx.doi.org/10.1002/mnfr.201600930] [PMID: 27943649]
[http://dx.doi.org/10.1371/journal.pone.0087861] [PMID: 24533060]
[http://dx.doi.org/10.1017/S0007114515002603] [PMID: 26268987]
[http://dx.doi.org/10.3390/nu9040324] [PMID: 28338639]
[http://dx.doi.org/10.1016/j.numecd.2018.03.007] [PMID: 29739677]
[http://dx.doi.org/10.3945/ajcn.114.093906] [PMID: 26245807]
[http://dx.doi.org/10.1097/GME.0000000000000305] [PMID: 25116050]
[http://dx.doi.org/10.1007/s10552-015-0534-3] [PMID: 25687481]
[http://dx.doi.org/10.1089/jmf.2015.0045] [PMID: 26670451]
[http://dx.doi.org/10.1007/s00125-014-3463-x] [PMID: 25533387]
[http://dx.doi.org/10.4236/ojemd.2015.51001]
[http://dx.doi.org/10.3164/jcbn.15-147] [PMID: 27698541]
[http://dx.doi.org/10.1002/mnfr.201501024] [PMID: 27004555]
[http://dx.doi.org/10.1016/j.diabres.2018.01.010] [PMID: 29407270]
[http://dx.doi.org/10.3233/JAD-142958] [PMID: 26401779]
[http://dx.doi.org/10.1016/j.tifs.2010.08.003]
[http://dx.doi.org/10.1055/s-0042-110179] [PMID: 27340792]
[http://dx.doi.org/10.3390/pharmaceutics6040599] [PMID: 25494200]
[http://dx.doi.org/10.1016/j.jfoodeng.2011.03.004]
[http://dx.doi.org/10.1007/s11101-014-9382-0]
[http://dx.doi.org/10.1016/j.fshw.2013.06.001]
[http://dx.doi.org/10.1016/j.jpba.2009.11.025] [PMID: 20036091]
[http://dx.doi.org/10.1590/S0100-40422010000300019]
[http://dx.doi.org/10.1016/j.carbpol.2013.06.062] [PMID: 23987405]
[http://dx.doi.org/10.3390/molecules22122183] [PMID: 29292784]
[http://dx.doi.org/10.1016/j.ijpharm.2011.09.044] [PMID: 22001794]
[http://dx.doi.org/10.1166/jbn.2013.1555] [PMID: 23621010]
[http://dx.doi.org/10.3109/10837450902882385] [PMID: 19883253]
[http://dx.doi.org/10.2147/IJN.S24185] [PMID: 22072878]
[http://dx.doi.org/10.1021/jf0488099] [PMID: 15769117]
[http://dx.doi.org/10.1016/j.carbpol.2017.02.025] [PMID: 28363543]
[http://dx.doi.org/10.1016/j.lwt.2007.09.001]
[http://dx.doi.org/10.1016/j.jfoodeng.2012.10.040]
[http://dx.doi.org/10.1016/j.ijpharm.2014.06.049] [PMID: 24979533]
[http://dx.doi.org/10.1186/s12906-017-1666-7] [PMID: 28381226]
[http://dx.doi.org/10.1016/S0308-8146(00)00306-X]
[http://dx.doi.org/10.1021/jf047838g] [PMID: 15853397]
[http://dx.doi.org/10.1021/jf052632g] [PMID: 16448186]
[http://dx.doi.org/10.1016/j.foodchem.2005.05.072]
[http://dx.doi.org/10.1016/j.foodchem.2010.04.023]
[http://dx.doi.org/10.1016/j.foodres.2015.05.044] [PMID: 28455027]
[http://dx.doi.org/10.1021/jf071773a] [PMID: 17960886]
[http://dx.doi.org/10.2174/1573401311666150610210529]
[http://dx.doi.org/10.1136/gut.2004.046292] [PMID: 15647180]
[http://dx.doi.org/10.1089/jmf.2012.0076] [PMID: 22892038]
[http://dx.doi.org/10.3892/ijo.2017.4088] [PMID: 28766690]
[http://dx.doi.org/10.1093/jn/137.12.2622] [PMID: 18029474]
[http://dx.doi.org/10.1158/1940-6207.CAPR-10-0359] [PMID: 21383028]
[http://dx.doi.org/10.1038/srep32516] [PMID: 27587238]
[http://dx.doi.org/10.1016/j.expneurol.2006.01.001] [PMID: 16480716]
[http://dx.doi.org/10.1089/jmf.2010.0170] [PMID: 21476926]
[http://dx.doi.org/10.1016/j.foodchem.2012.10.112] [PMID: 23692744]
[http://dx.doi.org/10.1016/j.foodres.2014.05.024]
[http://dx.doi.org/10.1089/jmf.2016.0152] [PMID: 28296588]
[http://dx.doi.org/10.1080/14786419.2015.1062005] [PMID: 26211432]
[http://dx.doi.org/10.1021/np200359v] [PMID: 21954959]
[http://dx.doi.org/10.1016/j.jfoodeng.2013.07.039]
[http://dx.doi.org/10.1089/jmf.2017.0016] [PMID: 28956697]
[http://dx.doi.org/10.1016/j.hpj.2016.05.001]
[http://dx.doi.org/10.1021/jf204452y] [PMID: 22224368]
[http://dx.doi.org/10.3390/12081641] [PMID: 17960080]
[http://dx.doi.org/10.1016/j.lwt.2014.02.060]
[http://dx.doi.org/10.1016/j.foodchem.2005.04.040]
[http://dx.doi.org/10.1016/S0960-8524(02)00167-0] [PMID: 12765356]
[http://dx.doi.org/10.1016/S0960-8524(03)00154-8] [PMID: 14585619]
[http://dx.doi.org/10.1021/ie101066m]
[http://dx.doi.org/10.1016/j.ifset.2015.07.005]
[http://dx.doi.org/10.1016/j.nut.2016.09.006] [PMID: 28063510]
[http://dx.doi.org/10.3390/molecules22050680] [PMID: 28448474]
[http://dx.doi.org/10.1016/j.jff.2017.11.015]
[http://dx.doi.org/10.1016/j.foodchem.2009.03.003]
[http://dx.doi.org/10.3109/07388550903425201] [PMID: 20148755]
[http://dx.doi.org/10.1080/10408398.2011.614702] [PMID: 24499066]
[http://dx.doi.org/10.12691/jfnr-1-3-1]
[http://dx.doi.org/10.1007/s10570-006-9095-7]
[http://dx.doi.org/10.1016/j.jssas.2016.07.006]
[http://dx.doi.org/10.1016/S0963-9969(00)00038-7]
[http://dx.doi.org/10.1111/nbu.12212]
[http://dx.doi.org/10.1016/j.carbpol.2015.09.063] [PMID: 26572430]
[http://dx.doi.org/10.1111/j.1745-4514.2009.00267.x]
[http://dx.doi.org/10.1271/bbb.70.178]
[http://dx.doi.org/10.1016/j.plipres.2003.10.002] [PMID: 15003396]
[http://dx.doi.org/10.1016/j.foodcont.2010.06.008]
[http://dx.doi.org/10.3390/medicines3040025] [PMID: 28930135]
[PMID: 28032110]
[http://dx.doi.org/10.1016/j.indcrop.2014.05.055]
[http://dx.doi.org/10.1016/j.jfda.2014.02.004] [PMID: 28911435]
[http://dx.doi.org/10.1016/j.lfs.2012.08.016] [PMID: 22935404]
[http://dx.doi.org/10.3390/molecules22081391] [PMID: 28829378]
[http://dx.doi.org/10.1016/j.foodchem.2006.11.054]
[http://dx.doi.org/10.3390/antiox4030498] [PMID: 26783839]
[http://dx.doi.org/10.1016/j.supflu.2018.03.015]
[http://dx.doi.org/10.1021/jf302815t] [PMID: 22957519]
[http://dx.doi.org/10.1007/s11746-014-2485-3]
[http://dx.doi.org/10.1155/2017/2867630] [PMID: 29230268]
[http://dx.doi.org/10.1007/s11130-014-0427-8] [PMID: 24928688]
[http://dx.doi.org/10.1016/j.indcrop.2013.07.048]
[http://dx.doi.org/10.20959/wjpps20164-6478]
[http://dx.doi.org/10.1016/j.foodchem.2016.09.016] [PMID: 27719891]
[http://dx.doi.org/10.1016/j.foodchem.2012.07.041] [PMID: 22980779]
[http://dx.doi.org/10.1016/j.fct.2018.03.050] [PMID: 29614383]
[http://dx.doi.org/10.1016/j.etap.2014.03.006] [PMID: 24691249]
[http://dx.doi.org/10.1155/2014/453972] [PMID: 25250322]
[http://dx.doi.org/10.1016/j.apjtm.2016.10.009] [PMID: 27955743]
[http://dx.doi.org/10.1016/j.foodres.2017.07.057] [PMID: 28873728]
[http://dx.doi.org/10.1016/j.lwt.2016.04.033]
[http://dx.doi.org/10.1080/10408398.2016.1229657] [PMID: 27646710]
[http://dx.doi.org/10.1016/S0891-5849(00)00226-4] [PMID: 10946210]
[http://dx.doi.org/10.1002/jsfa.8750] [PMID: 29064562]
[http://dx.doi.org/10.1016/j.desal.2005.06.060]
[http://dx.doi.org/10.1002/ffj.1604]
[http://dx.doi.org/10.1021/jf060348z] [PMID: 16719517]
[http://dx.doi.org/10.1016/j.jff.2013.12.021]
[http://dx.doi.org/10.1016/j.phanu.2015.10.001]
[http://dx.doi.org/10.1177/1934578X1100600707] [PMID: 21834231]
[http://dx.doi.org/10.1016/j.foodchem.2010.09.025]
[http://dx.doi.org/10.1038/srep20809] [PMID: 26853104]
[http://dx.doi.org/10.1371/journal.pone.0107431] [PMID: 25260046]
[http://dx.doi.org/10.1016/j.clnu.2014.11.012] [PMID: 25491246]
[http://dx.doi.org/10.3389/fphar.2016.00203] [PMID: 27471464]
[http://dx.doi.org/10.1016/j.lfs.2015.12.040] [PMID: 26764233]
[http://dx.doi.org/10.2174/1871520614666140829120530] [PMID: 25173561]
[http://dx.doi.org/10.1016/j.fitote.2014.02.009] [PMID: 24594241]
[http://dx.doi.org/10.1002/ptr.2971] [PMID: 19655295]
[http://dx.doi.org/10.1021/jf071772i] [PMID: 18038978]
[http://dx.doi.org/10.1016/j.fitote.2010.10.014] [PMID: 21056640]
[http://dx.doi.org/10.1021/jf5018324] [PMID: 24927513]
[http://dx.doi.org/10.1021/jf900489d] [PMID: 19422224]
[http://dx.doi.org/10.1016/j.foodchem.2008.02.060]
[http://dx.doi.org/10.1021/jf202449z] [PMID: 21819158]
[http://dx.doi.org/10.1021/jf062472o] [PMID: 17249682]
[http://dx.doi.org/10.1002/jsfa.2994]
[http://dx.doi.org/10.1021/np0704046] [PMID: 18163585]
[http://dx.doi.org/10.1016/j.foodchem.2014.07.107] [PMID: 25172755]
[http://dx.doi.org/10.3390/ijms18020392] [PMID: 28208804]
[http://dx.doi.org/10.1016/j.foodres.2017.08.063] [PMID: 28941682]
[http://dx.doi.org/10.1016/j.foodchem.2017.09.116] [PMID: 29120806]
[http://dx.doi.org/10.1016/j.carbpol.2017.06.109] [PMID: 28821105]
[http://dx.doi.org/10.1021/jf404549w] [PMID: 24313330]
[http://dx.doi.org/10.1021/acs.jafc.5b05404] [PMID: 26739867]
[http://dx.doi.org/10.1016/j.indcrop.2016.05.033]
[http://dx.doi.org/10.1016/j.jff.2012.11.001]
[http://dx.doi.org/10.1016/j.jff.2011.09.005]
[http://dx.doi.org/10.1002/jsfa.6871] [PMID: 25123494]
[http://dx.doi.org/10.1016/j.lwt.2015.03.113]
[http://dx.doi.org/10.1111/jfq.12246]