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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Phosphazene Base-Catalyzed Double Michael Addition: Stereoselective Synthesis of Cyclohexanones

Author(s): Yang-Guo Li, Yang Zhang, Guang-Fen Du*, Cheng-Zhi Gu and Lin He*

Volume 16, Issue 1, 2019

Page: [76 - 80] Pages: 5

DOI: 10.2174/1570178615666180912115748

Price: $65

Abstract

Phosphazene bases have been utilized as efficient organocatalysts to catalyze the double Michael additions of divinyl ketones with active methylenes to afford functionalized cyclohexanones in 36-91% yields with >25:1 diastereoselectivity.

Keywords: Phosphazene base, double Michael addition, cyclohexanone, organocatalysis, divinyl ketone, methylene.

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