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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Microwave-Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents

Author(s): Andrew McGown, Abby Ragazzon-Smith, John A. Hadfield, Herman Potgetier and Patricia A. Ragazzon*

Volume 16, Issue 1, 2019

Page: [66 - 75] Pages: 10

DOI: 10.2174/1570178615666180621094529

Price: $65

Abstract

In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bisflavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Keywords: Flavonoid, bis-flavonoid, green-chemistry, click-chemistry, microwave-assisted chemistry, anticancer.

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