Zinc Dependent Histone Deacetylase Inhibitors in Cancer Therapeutics: Recent Update

doi:10.2174/0929867325666180530094120
摘要

背景：组蛋白脱乙酰基酶（HDAC）是一类重要的酶，在基因表达的表观遗传调控中起着关键作用，后者修饰核心组蛋白的末端，导致染色质拓扑结构的重塑，从而控制基因表达。 HDAC抑制剂（HDACi）会抵消这一作用，并可能导致组蛋白的高度乙酰化，从而诱导一系列细胞后果，例如凋亡途径的激活，活性氧（ROS）的产生，细胞周期停滞和自噬。因此，人们对HDAC抑制剂作为新型靶向癌症治疗剂的潜在临床应用越来越感兴趣。方法和结果：本文回顾了2016年至2017年的几篇研究文章，目前就重要战略提供了重要见解，例如基于结构的合理药物设计，多参数导联优化方法，相关的SAR研究和各种生物学HDAC抑制剂（例如异羟肟酸，苯甲酰胺，环肽，脂肪族酸）的使用概述了迄今为止的各种组合药物治疗的临床试验和结果。结论：该综述将为合成化学家和生物学家提供一个平台，以满足分子靶向疗法和联合药物疗法在设计和合成癌症疗法中安全和选择性的HDAC抑制剂方面的需求。
关键词: 脂肪酸，苯甲酰苯胺，癌症治疗剂，环肽，组蛋白脱乙酰基酶，组蛋白脱乙酰基酶抑制剂和异羟肟酸。
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DOI https://dx.doi.org/10.2174/0929867325666180530094120	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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