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Review Article

基于基因工程的生物材料在生物医学中的应用

卷 26, 期 40, 2019

页: [7117 - 7146] 页: 30

弟呕挨: 10.2174/0929867325666180508094637

价格: $65

摘要

基于蛋白质的聚合物是新一代创新生物材料的最有希望的候选者，因为基因工程和生物技术的最新进展意味着可以以更高程度的复杂性和准确性设计和构建基于蛋白质的生物材料。此外，它们的序列（源自基于蛋白质的结构模块）可以轻松地进行修饰，以包含改善其功能和物质-宿主相互作用的生物活性基序，从而满足基本的生物学要求。这些高级多肽的生产准确性，多功能性，自组装行为，刺激反应性和生物相容性，意味着它们越来越受到生物医学应用的关注，例如细胞培养，组织工程，蛋白质纯化，表面工程和受控的药物输送。在这篇综述中讨论的生物聚合物是弹性蛋白衍生的基于蛋白质的聚合物，是生物启发和仿生材料。这篇综述还将侧重于这些遗传编码聚合物的设计，合成和表征，以及它们在受控药物和基因递送以及组织工程和再生医学中的潜在效用。

关键词: 药物输送，组织工程，弹性蛋白样重组子，纳米载体，水凝胶，刺激性反应，单体，自组装

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