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General Review Article

天然产物：抗锥虫病引起的被忽视疾病的药物发现的关键原型

卷 27, 期 13, 2020

页: [2133 - 2146] 页: 14

弟呕挨: 10.2174/0929867325666180501102450

价格: $65

摘要

背景：被忽视的热带病是由微生物和病毒引起的一组感染，主要影响世界贫困地区。另外，大多数可用药物与长期治疗和高毒性有关，这限制了应用和患者依从性。制药行业不认为对研发的投资具有吸引力，因为理想情况下最终产品必须便宜，并且不能返还所投资的金额。天然产物一直是生物活性化合物的重要来源，考虑到独特的结构多样性和生物活性，天然产物优于合成化合物。另一方面，隔离困难和低产率，对环境的影响和高成本通常限制了它们本身作为药物的应用。 目的：在这篇综述中，涵盖了使用天然产物作为半合成或全合成的原型，以及使用天然产物作为有希望的命中品，特别是针对具有抗锥虫病活性的化合物（如锥虫）的化合物。和利什曼原虫属。 方法：采用这种方法从文献中检索选定的报告。 结论：综上所述，可以得出结论，天然产品是设计针对这些寄生虫的新型药物的低估来源。

关键词: 天然产物，被忽视的疾病，原型，半合成衍生物，合成衍生物，锥虫病。

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