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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Mechanism and Inhibition of Matrix Metalloproteinases

Author(s): Linda Cerofolini, Marco Fragai* and Claudio Luchinat*

Volume 26, Issue 15, 2019

Page: [2609 - 2633] Pages: 25

DOI: 10.2174/0929867325666180326163523

Price: $65

Abstract

Matrix metalloproteinases hydrolyze proteins and glycoproteins forming the extracellular matrix, cytokines and growth factors released in the extracellular space, and membrane-bound receptors on the outer cell membrane. The pathological relevance of MMPs has prompted the structural and functional characterization of these enzymes and the development of synthetic inhibitors as possible drug candidates. Recent studies have provided a better understanding of the substrate preference of the different members of the family, and structural data on the mechanism by which these enzymes hydrolyze the substrates. Here, we report the recent advancements in the understanding of the mechanism of collagenolysis and elastolysis, and we discuss the perspectives of new therapeutic strategies for targeting MMPs.

Keywords: Matrix metalloproteinases, enzyme, mechanism, collagenolysis, elastolysis, inhibitor.

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