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Current Pharmaceutical Analysis

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ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

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Research Article

A Comparative Pharmacokinetic Profile of Trahydropalmatine After Oral Administration of its Monomer, Rhizoma Corydalis Alkaloid Extracts and Tong-Bi-Si-Wei-Fang to Rats

Author(s): Lijun Ni, Lu Ding, Liguo Zhang* and Shaorong Luan

Volume 15, Issue 4, 2019

Page: [338 - 345] Pages: 8

DOI: 10.2174/1573412914666180314122512

Price: $65

Abstract

Background: Tong-Bi-Si-Wei-Fang (TBSWF) is a candidate formula of Traditional Chinese Medicine (TCM) for treating rheumatoid bone diseases, which is composed of rhizoma corydalis alkaloids, saponins of glycyrrhiza uralensis and panax notoginseng, flavonoids of rhizoma drynariae and glycyrrhiza uralensis.

Objective: Trahydropalmatine (THP), the main active ingredient of rhizoma corydalis alkaloids, was selected to study in vivo pharmacokinetics and druggability of TBSWF.

Methods: The plasma concentration-time (C-T) profiles of THP and the pharmacokinetic property parameters after oral administration of THP monomer, extract of corydalis alkaloids (ECA) and TBSWF to rats, respectively were compared by a fully-validated HPLC method.

Results: Compared to the THP monomer, the THP in TBSWF is absorbed faster, resides in the plasma longer and has a similar apparent volume of distribution Vz/F (10~20 L/kg). Compared to THP monomer and THP in TBSWF, the area under the concentration-time curve AUC 0-t of THP in ECA decreases two-third; Vz/F of THP in ECA (85.02 L/kg) is significantly higher than that of THP in TBSWF(p <0.05). Unlike THP monomer and THP in ECA, double peaks are observed in the C-T profile of THP after oral administration of TBSWF. THP in TBSWF exhibits slow release to a certain degree.

Conclusion: The interactions among the ingredients of TBSWF promote the adsorption and prolong the residence time of THP in vivo, and provide an explanation for the advantages of TBSWF from the point of pharmacokinetics.

Keywords: Pharmacokinetics, Tong-Bi-Si-Wei-Fang, tetrahydropalmatine, Rhizoma corydalis alkaloid, LC, rat plasma.

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[1]
Ni, L.J.; Zhang, L.G.; Zhao, W.W. A Traditional Chinese medicine parts formula and the preparation method on treating rheumatoid bone.China Patent CN201410294337.8, Oct 15,2014
[2]
Ni, L.J.; Yan, W.T.; Zhang, L.G.; Ding, L.; Shi, W.Z. In vivo therapeutic effect study of Tongbisiwei Fang based on Combination of Traditional Chinese medicine effective parts. Tradit. Chin. Drug Res. Clin. Pharmacol., 2016, 27(5), 666-667.
[3]
Ni, L.J.; Ding, L.; Zhang, L.G.; Yan, W.T. Shi. W.Z. Effect of a Traditional Chinese medicine effective parts formula Tongbisiwei Fang on treating adjuvant arthritis in rats and in vivo immunomodulation. Tradit. Chin. Drug Res. Clin. Pharmacol, 2017, 28(05), 616-621.
[4]
Pharmacopeia Committee of PR China. Pharmacopeia of the People’s Republic of China, 2015 edition; Chinese Medical Science and Technology Press: Beijing, 2015, pp. 1655-1658.
[5]
Zhang, L.G.; Wang, X.M.; Ni, L.J.; Ma, D.S. The acute toxicity research of two kinds of traditional Chinese medicine candidate formula for curing rheumatoid bone diseases. Chin. Tradit. Patent Med., 2017, 39(8), 1723-1724.
[6]
Wang, S.P.; Hu, Y.Y.; Tan, W. Compatibility art of traditional Chinese medicine: From the perspective of herb pairs. J. Ethnopharmacol., 2012, 143(2), 412-423.
[7]
Sagare, A.P.; Lee, Y.L.; Lin, T.C.; Chen, C.C.; Tsay, H.S. Cytokinin-induced somatic embryogenesis and plant regeneration in Corydalis yanhusuo (Fumariaceae)-a medicinal plant. Plant Sci., 2001, 160(1), 139-147.
[8]
Rong, L.; Niu, Y.B.; Dou, Z.Y. Comparative study for pharmacological action of Corydalis rhizoma before and after processing. Chin. Herb. Med., 2015, 7(3), 247-254.
[9]
Gao, Y.; Hu, S.; Zhang, M.; Li, L.L.; Lin, Y.N. Simultaneous Determination of four alkaloids in mice plasma and brain by LC-MS/Ms for pharmacokinetic studies after administration of Corydalis rhizoma and Yuanhu zhitong extracts. J. Pharm. Biomed. Anal., 2014, 92, 6-8.
[10]
Ding, B.; Zhou, T.T.; Fan, G.R.; Hong, Z.Y.; Wu, Y.T. Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC-MS/MS and LC-DAD. J. Pharm. Biomed. Anal., 2007, 45(2), 219-226.
[11]
Yu, L.; Tan, J.; Wink, M.; Ma, Y.G.; Li, N.; Su, G.N. An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1. Food Chem., 2013, 136, 1117-1121.
[12]
Kang, K.H.; Kong, C.S.; Seo, Y.; Kim, M.M.; Kim, S.K. Anti-inflammatory effect of coumarins isolated from Corydalis heterocarpa in HT-29 human colon carcinoma cells. Food Chem. Toxicol., 2009, 47, 2129-2134.
[13]
Liu, Y.L.; Yan, L.D.; Zhou, P.L.; Wu, C.F.; Gong, Z.H. Levo-tetrahydropalmatine attenuates oxycodone-induced conditioned place preference in rats. Eur. J. Pharmacol., 2009, 602(2), 321-322.
[14]
Mantsch, J.R.; Li, S.J.; Risinger, R.; Awad, S.; Katz, E.; Baker, D.A.; Zheng, Y. Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats. Psychopharmacology, 2007, 192, 581-591.
[15]
Xi, Z.X.; Yang, Z.; Li, S.J.; Li, X.; Dillon, C.; Peng, X.Q. Levo-tetrahydropalmatine inhibits cocaine’s rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology, 2007, 53, 771-782.
[16]
Chang, C.K.; Lin, M.T. DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats. Neurosci. Lett., 2001, 307, 163-166.
[17]
Chang, C.K.; Chueh, F.Y.; Hsieh, M.T.; Lin, M.T. The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke. Neurosci. Lett., 1999, 267, 109-112.
[18]
Lin, M.T.; Chueh, F.Y.; Hsieh, M.T.; Chen, C.F. Antihypertensive effects of dl-tetrahydropalmatine: an active principle isolated from Corydalis. Clin. Exp. Pharmacol. Physiol., 1996, 23(8), 738-739.
[19]
Ding, G.S. Important Chinese herbal remedies. Clin. Ther., 1987, 9(4), 345-357.
[20]
Tran, S.C.; Duc, N.D.; Tung, N.T. Pharmacokinetic analysis of levo-tetrahydropalmatine in rabbit plasma by rapid sample preparation and liquid chromatography-tandem mass spectrometry. J. Chromatogr. B, 2016, 1008, 81-82.
[21]
Pharmacopeia Committee of PR China. Pharmacopeia of the People’s Republic of China; Chinese Medical Science and Technology Press: Beijing, 2015, pp. 139-140.
[22]
Ma, H.D.; Wang, Y.J.; Guo, T.; He, Z.G.; Chang, X.Y.; Pu, X.H. Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study. J. Pharm. Biomed. Anal., 2009, 49(2), 440-446.
[23]
Liu, X.Y. Pharmacokinetic of tetrahydropalmatine in rats. J. Nanjing Univ. Tradit. Chin. Med., 2012, 28(6), 555-557.
[24]
Wang, S.; Liu, L.; Wang, L.; Jiang, P.; Xiang, L.; Zhang, W.; Liu, R. Development and validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of four tertiary alkaloids in rat plasma and its application to a pharmacokinetic study. J. Pharm. Biomed. Anal., 2013, 72, 80-88.
[25]
Hu, N.; Liang, R.X.; Wang, L. Pharmacokinetics study of corydalis extracts in rat plasma. Chin. J. Exp. Tradit. Med. Formulae,, 2011, 17(4), 186-190.
[26]
Li, Q.Y.; Li, K.T.; Sun, H. LC-MS/MS Determination and pharmacokinetic study of dehydrocorydaline in rat plasma after oral administration of dehydrocorydaline and corydalis yanhusuo extract. Molecules, 2014, 19(10), 16312-16326.
[27]
Zhang, X.R.; Guan, J.; Zhu, H.Y. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. J. Chromatogr. B , 2014, 971(15), 126-132.
[28]
Ai, Y.; Wu, Y.; Wang, F.R.A. UPLC-MS/MS method for simultaneous quantitation of three monoterpene glycosides and four alkaloids in rat plasma: application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and single herb extract. J. Mass Spectrom., 2015, 50(3), 567-577.
[29]
Huang, X.C.; Su, S.L.; Cui, W.X. Simultaneous determination of paeoniflorin, albiflorin, ferulic acid, tetrahydropalmatine, protopine, typhaneoside, senkyunolide I in Beagle dogs plasma by UPLC-MS/MS and its application to a pharmacokinetic study after Oral Administration of Shaofu Zhuyu Decoction. J. Chromatogr. B, 2014, 962, 75-81.
[30]
Zhang, J.; Sui, Q.J.; Wang, C. Quantification of glycyrrhetic acid in human plasma by LC-MS/MS: application to a pharmacokinetic study. Curr. Pharm. Anal., 2017, 13(4), 334-339.
[31]
Zhang, L.G.; Fang, C.Y.; Ouyang, X.W. Simultaneous determination of saponins in Radix glycyrrhizae, Notoginseng and Ginseng by high performance liquid chromatography. Trans. Tianjin. Univ., 2013, 19, 430-435.
[32]
Fang, C.Y. Preparation, Analysis and Activity Evaluation of Saponins in Yaotongning Prescription, Notoginseng and Ginseng., PhD Thesis, East China University of Science and Technology: Shanghai. 2013.
[33]
Yan, Z.H. Preparation technology optimization and quality analysis of effective fractions in a candidate rheumatism disease treatment formula and quality analysis of the formula., PhD Thesis, East China University of Science and Technology: Shanghai. 2015.
[34]
Zhang, Z.Q. Research on Technology of Applying Macroporous Adsorption Resin to Separate Flavonoids of Herbs and Design of the Production Line., PhD Thesis, East China University of Science and Technology: Shanghai. 2013.
[35]
Duan, J.Z.; Dang, Y.; Meng, H.J. A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration. Eur. J. Drug Metab. Pharmacokinet., 2016, 41, 239-249.
[36]
Wang, G.J.; Liu, X.D.; Liu, X.Q. Pharmacokinetics; Chemical Industry Press: Beijing, 2006.

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