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General Review Article

基于金属有机框架（MOF）的生物医学纳米材料

卷 26, 期 18, 2019

页: [3341 - 3369] 页: 29

弟呕挨: 10.2174/0929867325666180214123500

价格: $65

摘要

背景：金属有机骨架（MOF）作为一类新型的由金属原子和有机支柱的自组装而成的多孔有机-无机晶体杂化材料，由于其特殊的性能而引起了极大的关注。 最近，更多文献报道了不同类型的纳米级金属有机框架（NMOF），它们是可生物降解的生理pH响应系统，用于体内的光热疗法和放射疗法。 讨论：在这篇综述中，本文旨在描述在生物医学领域中使用MOF纳米颗粒的好处，并结合其他纳米颗粒的特性对其进行了展望。 第一部分简要回顾了MOF的生物材料支架。 第二部分从两类类别中介绍了刺激响应机制和策略的主要类型：内在性（pH，氧化还原状态）和外在性（温度，光辐射和磁场）。 已经详细总结了光热疗法和放射疗法的组合。 最后，还提到了MOF的临床应用，未来的挑战和前景。 结论：这篇综述概述了MOFs设计和生物医学应用的最新进展，从不同的合成到用作智能药物输送系统，生物成像技术或两者的结合。

关键词: 药物传递系统(DDSs)，建筑单元(SBU)，光学成像(OI)， MOFs，纳米材料，生物医学应用。

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