[1]
Rani, J.; Kumar, S.; Saini, M.; Mundlia, J.; Verma, P.K. Biological potential of pyrimidine derivatives in a new era. Res. Chem. Intermed., 2016, 42, 6777-6804.
[2]
Cocco, M.T.; Congiu, C.; Onnis, V.; Piras, R. Synthesis and antitumor evaluation of 6-thioxo-, 6-oxo- and 2,4-dioxopyrimidine derivatives. Farmaco, 2001, 56(10), 741-748.
[3]
Meneghesso, S.; Vanderlinden, E.; Stevaert, A.; McGuigan, C.; Balzarini, J.; Naesens, L. Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus. Antiviral Res., 2012, 94(1), 35-43.
[4]
Anupama, B.; Dinda, S.C.; Prasad, Y.R.; Rao, A.V. Synthesis and antimicrobial activity of some new 2,4,6-trisubstituted pyrimidines. Int. J. Res. Pharm. Chem., 2012, 2(2), 231-236.
[5]
Tozkoparan, B.; Ertan, M.; Kelicen, P.; Demirdamar, R. Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives. Farmaco, 1999, 54(9), 588-593.
[6]
Ashour, H.M.; Shaaban, O.G.; Rizk, O.H.; El-Ashmawy, I.M. Synthesis and biological evaluation of thieno [2′,3′:4,5]pyrimido[1,2-b][1,2,4]triazines and thieno[2,3-d][1,2,4]triazolo[1,5-a]pyrimidines as anti-inflammatory and analgesic agents. Eur. J. Med. Chem., 2013, 62, 341-351.
[7]
Bhalgat, C.M.; Ali, M.I.; Ramesh, B.; Ramu, G. Novel pyrimidine and its triazole fused derivatives: synthesis and investigation of antioxidant and anti-inflammatory activity. Arab. J. Chem., 2014, 7, 986-993.
[8]
Kumar, D.; Khan, S.I.; Tekwani, B.L.; Ponnan, P.; Rawat, D.S. 4-Aminoquinoline-pyrimidine hybrids: synthesis, antimalarial activity, heme binding and docking studies. Eur. J. Med. Chem., 2015, 89, 490-502.
[9]
El-Sayed, N.S.; El-Bendary, E.R.; El-Ashry, S.M.; El-Kerdawy, M.M.; El-Kerdawy, M.M. Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2-a]pyrimidines. Eur. J. Med. Chem., 2011, 46(9), 3714-3720.
[10]
Abbas, S.E.; Abdel Gawad, N.M.; George, R.F.; Akar, Y.A. Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives. Eur. J. Med. Chem., 2013, 65, 195-204.
[11]
Hafez, H.N.; El-Gazzar, A.B.A.; Al-Hussain, S.A.; Al-Hussain, S.A. Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. Bioorg. Med. Chem. Lett., 2016, 26(10), 2428-2433.
[12]
Fares, M.; Abou-Seri, S.M.; Abdel-Aziz, H.A.; Abbas, S.E.S.; Youssef, M.M.; Eladwy, R.A. Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest. Eur. J. Med. Chem., 2014, 83, 155-166.
[13]
Hu, Y-G.; Wang, Y.; Du, S-M.; Chen, X-B.; Ding, M-W. Efficient synthesis and biological evaluation of some 2,4-diamino-furo[2,3-d]pyrimidine derivatives. Bioorg. Med. Chem. Lett., 2010, 20(21), 6188-6190.
[14]
Naresh Kumar, R.; Poornachandra, Y.; Nagender, P.; Mallareddy, G.; Ravi Kumar, N.; Ranjithreddy, P.; Ganesh Kumar, C.; Narsaiah, B. Synthesis of novel trifluoromethyl substituted furo[2,3-b]pyridine and pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as potential anticancer agents. Eur. J. Med. Chem., 2016, 108, 68-78.
[15]
Huang, Y.Y.; Wang, L.Y.; Chang, C.H.; Kuo, Y.H.; Kaneko, K.; Takayama, H.; Kimura, M.; Juang, S.H.; Wong, F.F. One-pot synthesis and antiproliferative evaluation of pyrazolo[3,4-d]pyrimidine derivatives. Tetrahedron, 2012, 68, 9658-9664.
[16]
Mohareb, R.M.; Abbas, N.S.; Abdelaziz, M.A. Heterocyclic ring extension of androstenedione: synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives. Steroids, 2014, 86, 45-55.
[17]
Nagarapu, L.; Vanaparthi, S.; Bantu, R.; Ganesh Kumar, C. Synthesis of novel benzo[4,5]thiazolo[1,2-a]pyrimidine-3-carboxylate derivatives and biological evaluation as potential anticancer agents. Eur. J. Med. Chem., 2013, 69, 817-822.
[18]
Song, X.J.; Shao, Y.; Dong, X.G. Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents. Chin. Chem. Lett., 2011, 22, 1036-1038.
[19]
Prajapti, S.K.; Nagarsenkar, A.; Guggilapu, S.D.; Gupta, K.K.; Allakonda, L.; Jeengar, M.K.; Naidu, V.G.M.; Babu, B.N. Synthesis and biological evaluation of oxindole linked indolyl-pyrimidine derivatives as potential cytotoxic agents. Bioorg. Med. Chem. Lett., 2016, 26(13), 3024-3028.
[20]
Tangeda, S.J.; Garlapati, A. Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives and evaluation of their activities against human colon cancer cell lines. Eur. J. Med. Chem., 2010, 45(4), 1453-1458.
[21]
Rashad, A.E.; Mahmoud, A.E.; Ali, M.M. Synthesis and anticancer effects of some novel pyrazolo[3,4-d]pyrimidine derivatives by generating reactive oxygen species in human breast adenocarcinoma cells. Eur. J. Med. Chem., 2011, 46(4), 1019-1026.
[22]
Chen, P-J.; Yang, A.; Gu, Y-F.; Zhang, X-S.; Shao, K-P.; Xue, D-Q.; He, P.; Jiang, T.F.; Zhang, Q.R.; Liu, H.M. Synthesis, in vitro antimicrobial and cytotoxic activities of novel pyrimidine-benzimidazol combinations. Bioorg. Med. Chem. Lett., 2014, 24(12), 2741-2743.
[23]
Zhu, W.; Liu, Y.; Zhai, X.; Wang, X.; Zhu, Y.; Wu, D.; Zhou, H.; Gong, P.; Zhao, Y. Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents. Eur. J. Med. Chem., 2012, 57, 162-175.
[24]
Guo, X.; Li, Y.; Tao, L.; Wang, Q.; Wang, S.; Hu, W.; Pan, Z.; Yang, Q.; Cui, Y.; Ge, Z.; Dong, L.; Yu, X.; An, H.; Song, C.; Chang, J. Synthesis and anti-HIV-1 activity of 4-substituted-7-(2′-deoxy-2′-fluoro-4′-azido-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine analogues. Bioorg. Med. Chem. Lett., 2011, 21(22), 6770-6772.
[25]
Xu, X.; Wang, J.; Yao, Q. Synthesis and quantitative structure-activity relationship (QSAR) analysis of some novel oxadiazolo[3,4-d]pyrimidine nucleosides derivatives as antiviral agents. Bioorg. Med. Chem. Lett., 2015, 25(2), 241-244.
[26]
Rashad, A.E.; Hegab, M.I.; Abdel-Megeid, R.E.; Micky, J.A.; Abdel-Megeid, F.M.E. Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives. Bioorg. Med. Chem., 2008, 16(15), 7102-7106.
[27]
Sari, O.; Roy, V.; Métifiot, M.; Marchand, C.; Pommier, Y.; Bourg, S.; Bonnet, P.; Schinazi, R.F.; Agrofoglio, L.A. Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase. Eur. J. Med. Chem., 2015, 104, 127-138.
[28]
Hocková, D.; Holý, A.; Masojídková, M.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds. Bioorg. Med. Chem., 2004, 12(12), 3197-3202.
[29]
Srivastav, N.C.; Mak, M.; Agrawal, B.; Tyrrell, D.L.J.; Kumar, R. Antiviral activity of 2,3′-anhydro and related pyrimidine nucleosides against hepatitis B virus. Bioorg. Med. Chem. Lett., 2010, 20(22), 6790-6793.
[30]
Tian, Y.; Du, D.; Rai, D.; Wang, L.; Liu, H.; Zhan, P.; De Clercq, E.; Pannecouque, C.; Liu, X. Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives. Bioorg. Med. Chem., 2014, 22(7), 2052-2059.
[31]
Lu, H-H.; Xue, P.; Zhu, Y-Y.; Ju, X-L.; Zheng, X-J.; Zhang, X.; Xiao, T.; Pannecouque, C.; Li, T-T.; Gu, S-X. Structural modifications of diarylpyrimidines (DAPYs) as HIV-1 NNRTIs: Synthesis, anti-HIV activities and SAR. Bioorg. Med. Chem., 2017, 25(8), 2491-2497.
[32]
Amblard, F.; Aucagne, V.; Guenot, P.; Schinazi, R.F.; Agrofoglio, L.A. Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series. Bioorg. Med. Chem., 2005, 13(4), 1239-1248.
[33]
Kim, J.; Kwon, J.; Lee, D.; Jo, S.; Park, D-S.; Choi, J.; Park, E.; Hwang, J.Y.; Ko, Y.; Choi, I.; Ju, M.K.; Ahn, J.; Kim, J.; Han, S-J.; Kim, T-H.; Cechetto, J.; Nam, J.; Ahn, S.; Sommer, P.; Liuzzi, M.; Lee, J. Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors. Bioorg. Med. Chem. Lett., 2014, 24(23), 5473-5477.