Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent

Title:Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent

Volume: 18 Issue: 7

Author(s): Santosh N. Mokale*, Nikhil S. Sakle, Swati A. Bhavale, Deepak K. Lokwani and Vishakha R. Shelke

Affiliation:

• Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad-431001, Maharashtra,India

Keywords: Chalcone, isoxazole, breast cancer, estrogen receptor, S21-S30, tamoxifen.

Abstract: Methods: A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has the ability to inhibit the growth of the human breast cancer cell line at low concentrations. In vivo anticancer activity was performed on virgin female sprague dawley rats.

Results: The result shows that compound S23 has more selectivity and marked estrogen modulator activity than the standard tamoxifen.

Cite this article as:

Mokale N. Santosh *, Sakle S. Nikhil , Bhavale A. Swati , Lokwani K. Deepak and Shelke R. Vishakha , Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (7) . https://dx.doi.org/10.2174/1871520618666171129153655