Recent Patents and Formulation of Nanopharmaceuticals Using Ultrasonication Technique

Title:Recent Patents and Formulation of Nanopharmaceuticals Using Ultrasonication Technique

Volume: 12 Issue: 2

Author(s): Nidhi Saiwal, Mandeep Dahiya and Harish Dureja*

Affiliation:

• Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001,India

Keywords: Cavitation, chemotherapy, hyperthermia, microbubbles, targeted, ultrasound, liposomes, protein.

Abstract: Background: Ultrasound (US) has the ever-rising role in the delivery of therapeutic agents that includes chemotherapeutic agents, proteins, and genetic material. The microbubbles are the cavitating gas bodies that act as the mediators through which the energy of relatively non-interactive pressure waves is accumulated to produce forces that can permeabilize cell membranes and disrupt the vesicles that carry the therapeutic agent. This shows that the microbubbles greatly enhance the delivery of smaller chemical agents, proteins and genetic material.

Method: Various databases of online literature and patented reports based on sonication were reviewed.

Results and Conclusion: The literature reveals that US-assisted drug delivery is used in the delivery of therapeutic agents into various tissues including vascular, cardiac, tumor, skeletal muscle and fetal tissue. US-assisted delivery of proteins has been studied in the application in transdermal delivery of insulin, hormones and small proteins. Cavitation effect occurring during the sonication reversibly disrupts the stratum corneum structure to allow the transport of the large molecules. Cavitation disrupts the structure of the carrier vesicle and releases the drug. But there still remains a need for better understanding the physics of cavitation of microbubbles and the impact of cavitation on drug-carrying vesicles and cells. Ultrasonic technology has been proven effective at creating encapsulating particles and droplets with specific physical and functional properties. This article provides an overview of the factors influencing ultrasonication and various nanosystems formulated by using this technology.

Cite this article as:

Saiwal Nidhi, Dahiya Mandeep and Dureja Harish*, Recent Patents and Formulation of Nanopharmaceuticals Using Ultrasonication Technique, Recent Patents on Nanotechnology 2018; 12 (2) . https://dx.doi.org/10.2174/1872210511666171120100649