摘要
肽疗法在过去十年取得了巨大进步。随着最近在综合药物发现环境中的科学和技术进步，现在或多或少地有效地解决了肽的许多固有弱点，这些弱点阻碍了它们作为治疗剂的发展。这些包括合成有机化学的最新发展，高通量重组生产策略，高分辨率分析方法，高通量筛选选项，巧妙的药物递送策略和新型制剂制剂。在这里，我们将简要介绍治疗性肽开发过程中使用的关键方法和策略，并选择该领域最新发展的实例。本综述的目的是强调药物化学家可能考虑的可行选择，以便改善肽导联实体中感兴趣的特定药理学特性，从而合理地评估这类分子在传统上（和不正确的）具有的治疗潜力。 ）被认为是“不可挽回的”。
关键词: 治疗肽，固相肽合成，高通量筛选，钉合肽，非天然氨基酸，脂质体包封，环肽/拟肽，细胞穿透肽。
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