Impact of Red Wine Consumption on Cardiovascular Health

doi:10.2174/0929867324666170518100606
摘要

背景：长期以来，大量饮酒的破坏性作用已得到公认。在过去的几十年中，人们提出了适量喝红酒的潜在好处。在不能大量摄入红葡萄酒的欧洲国家（例如法国），胆固醇与心血管疾病（CV）风险之间的联系并不明显，这表明红酒或其他食品和饮料中某些保护性分子的作用。方法：该叙述性评论基于截至2016年5月通过PubMed搜索并获得的材料。我们使用的搜索词为：“红酒，心血管，酒精”与“多酚，心力衰竭，梗塞”组合。结果：红酒摄入量和简历风险之间呈J形关系的流行病学和机理证据进一步支持了“法国悖论”。发现了体外和动物模型中红酒的特定成分。多酚，尤其是白藜芦醇主要通过抗氧化特性对预防CV做出了很大贡献。它们对内皮功能障碍和高血压，血脂异常，代谢疾病产生有益作用，从而降低了不良CV事件（如心肌梗死，缺血性中风和心力衰竭）的风险。有趣的是，最近的研究指出了乙醇本身作为潜在的心脏保护剂的作用，但是仍然缺少明确的流行病学证据。这篇叙述性综述的目的是为了更新有关多酚和乙醇的心脏保护作用的细胞内机制的最新知识。此外，我们总结了流行病学研究的结果，强调其方法学上的批评以及需要进行随机临床试验以阐明红酒消费在降低CV风险中的潜在作用。结论：特别注意避免低估酒精相关疾病的总体负担。
关键词: 酒精，乙醇，类黄酮，多酚，红酒，白藜芦醇。
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DOI https://dx.doi.org/10.2174/0929867324666170518100606	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

红酒消费对心血管健康的影响

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当代药物化学

红酒消费对心血管健康的影响

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