Abstract
Barbituric acid derivatives exert important action on the central nervous system, and recently have found totally new biomedicinal applications in fields such as cancer and AIDS therapy, and protease inhibitors. On the other hand, selective introduction of fluorine into biologically active compounds can either enhance their pharmacological properties or increase their therapeutic efficiency. This review focuses on the synthesis and the biological properties of fluorinated barbituric acid derivatives, which can be divided into three main categories: 1) those bearing a fluorine directly bound in position 5 of the 2,4,6-trioxohexahydro-pyrimidine ring, 2) 5-fluoroalkyl derivatives, and 3) 5-fluoroaryl derivatives.
Keywords: fluorinated barbituric acid derivatives, barbituric acid derivatives, trioxohexahydro-pyrimidine ring, 5-fluoroaryl derivatives
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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