Comparison of the Characteristics and Performance of Flurbiprofen 8.75 mg Spray for Sore Throat

Title:Comparison of the Characteristics and Performance of Flurbiprofen 8.75 mg Spray for Sore Throat

Volume: 14 Issue: 5

Author(s): David Veale, Adrian Shephard*, Verity Adams and Charlotte Lidster

Affiliation:

• Reckitt Benckiser Healthcare International Ltd, 103-105 Bath Road, Slough, Berkshire, SL1 3UH,United Kingdom

Keywords: Droplet size, drug delivery, flurbiprofen, oral spray, pharyngitis, spray angle, spray pattern.

Abstract: Background: Sore throat sprays provide targeted relief by delivering the active ingredient directly to the site of pain. Different sprays vary in characteristics, thus affecting delivery of the active ingredient to the throat, which can impact compliance.

Objective: The characteristics and performance of FLURBIPROFEN 8.75 mg SPRAY were compared with 12 other sprays.

Method: Parameters assessed included spray angle and pattern, droplet size distribution, shot weight uniformity and shot weight throughout life.

Results: Among all sprays tested WICK Sulagil Halsspray had the smallest spray angle (46°) and also the smallest diameter spray pattern (X=32.8 mm; Y=34.4 mm). Thiovalone® Buccal Spray Suspension had both the largest spray angle (82°) and largest diameter spray pattern (X=62.6 mm; Y=78.0 mm). Hasco Sept® Aerosol Spray had the smallest droplet size (Dv90=118.4 μm) whereas OKi infiammazione e dolore® 0.16% spray had the largest (Dv90=214.34 μm). In terms of shot weight uniformity, TANTUM® VERDE GOLA 0.25% spray showed the least variation (2% RSD) between shots and UNIBEN Aerosol Spray the most (23.4% RSD). Shot weight throughout life studies showed that FLURBIPROFEN 8.75 mg SPRAY had the least deviation from shot weight (1.77%) whereas OKi infiammazione e dolore® 0.16% spray deviated the most (44.9%). FLURBIPROFEN 8.75 mg SPRAY had the second smallest spray angle/pattern and droplet size distribution and also the least variation in shot weight.

Conclusion: Different sore throat sprays vary in different attributes, affecting delivery of the active ingredient. FLURBIPROFEN 8.75 mg SPRAY performed well overall, ranking first among all sprays tested, and providing a dose which is targeted and uniformly delivered throughout the life of the bottle.

Cite this article as:

Veale David, Shephard Adrian*, Adams Verity and Lidster Charlotte, Comparison of the Characteristics and Performance of Flurbiprofen 8.75 mg Spray for Sore Throat, Current Drug Delivery 2017; 14 (5) . https://dx.doi.org/10.2174/1567201813666161205155830

DOI https://dx.doi.org/10.2174/1567201813666161205155830	Print ISSN 1567-2018
Publisher Name Bentham Science Publisher	Online ISSN 1875-5704