Abstract
Excessive and persistent formation of ROS (reactive oxygen species) is a key factor in the origin of cancer, cardiac problems, inflammatory diseases, multiple organ dysfunction, aging and neurogenerative diseases. These ROS are produced from exogenous sources (ionizing radiation, chemicals and contaminants) and endogenous sources (Enzymes like Xanthine Oxidase and Monoamine Oxidase) which further originate a number of diseases along with genetic mutation. Due to the persistent side effects of synthetic antioxidants, there is flow towards naturally driven antioxidants as a large number of dietary supplements possess antioxidant potential. Coumarins are naturally occurring benzopyrones found in a variety of natural plants and exhibit different pharmacological properties. Among these activities the antioxidant potential of coumarins has been extensively studied that has been reviewed in this paper.
Keywords: Antioxidant, xanthine oxidase, monoamine oxidase, coumarins.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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